(rac)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine

Base Information

Chemical Name:(rac)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine
CAS No.:1610462-75-3
Molecular Formula:C₁₉H₂₀FN₅O₂S
Molecular Weight:401.465
Hs Code.:

Synonyms:(rac)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine

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Chemical Property of (rac)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (rac)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine

There total 8 articles about (rac)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610462-86-6
(rac)-2,2,2-trifluoro-N-{[(2-{[6-(4-fluoro-2-methoxyphenyl)pyrimidin-4-yl]amino}-6-methylpyridin-4-yl)methyl](methyl)-λ⁴-sulfanylidene}acetamide

: 1610462-75-3
(rac)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine

Guidance literature:: With Oxone; water; potassium hydroxide; In methanol; at 20 ℃; for 0.75h; pH=10 - 11;

Reference yield:

: 25462-85-5
2-chloro-6-methylpyridine-4-carboxylic acid

: 1610462-75-3
(rac)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: borane-THF / tetrahydrofuran / 0 - 20 °C

2.1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 10 °C

3.1: water; acetone / 20 °C

4.1: 1-methyl-pyrrolidin-2-one; XPhos; potassium phosphate; chloro(2-dicyclohexylphosphino-2',4',6'-tri-iso-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-tert-butyl ether adduct / toluene / 4 h / 130 °C / Inert atmosphere; Sealed tube

5.1: sodium t-butanolate; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / tetrahydrofuran / 0.17 h / 10 °C / Inert atmosphere

5.2: 1.25 h / 10 °C / Inert atmosphere

6.1: potassium hydroxide; Oxone; water / methanol / 0.75 h / 20 °C / pH 10 - 11

With 1-methyl-pyrrolidin-2-one; Oxone; potassium phosphate; thionyl chloride; borane-THF; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; chloro(2-dicyclohexylphosphino-2',4',6'-tri-iso-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-tert-butyl ether adduct; water; potassium hydroxide; sodium t-butanolate; XPhos; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 152815-18-4
(2-chloro-6-methyl-pyridin-4-yl)-methanol

: 1610462-75-3
(rac)-6-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 10 °C

2.1: water; acetone / 20 °C

3.1: 1-methyl-pyrrolidin-2-one; XPhos; potassium phosphate; chloro(2-dicyclohexylphosphino-2',4',6'-tri-iso-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-tert-butyl ether adduct / toluene / 4 h / 130 °C / Inert atmosphere; Sealed tube

4.1: sodium t-butanolate; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / tetrahydrofuran / 0.17 h / 10 °C / Inert atmosphere

4.2: 1.25 h / 10 °C / Inert atmosphere

5.1: potassium hydroxide; Oxone; water / methanol / 0.75 h / 20 °C / pH 10 - 11

With 1-methyl-pyrrolidin-2-one; Oxone; potassium phosphate; thionyl chloride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; chloro(2-dicyclohexylphosphino-2',4',6'-tri-iso-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-tert-butyl ether adduct; water; potassium hydroxide; sodium t-butanolate; XPhos; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; toluene;