(4-Amino-5-oxo-3-phenyl-4,5-dihydro-[1,2,4]triazol-1-yl)-acetic acid ethyl ester

Base Information

• Chemical Name: (4-Amino-5-oxo-3-phenyl-4,5-dihydro-[1,2,4]triazol-1-yl)-acetic acid ethyl ester
• CAS No.: 96240-14-1
• Molecular Formula: C₁₂H₁₄N₄O₃
• Molecular Weight: 262.268
• Mol file: 96240-14-1.mol

Synonyms:(4-Amino-5-oxo-3-phenyl-4,5-dihydro-[1,2,4]triazol-1-yl)-acetic acid ethyl ester

Chemical Property of (4-Amino-5-oxo-3-phenyl-4,5-dihydro-[1,2,4]triazol-1-yl)-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-Amino-5-oxo-3-phenyl-4,5-dihydro-[1,2,4]triazol-1-yl)-acetic acid ethyl ester

There total 2 articles about (4-Amino-5-oxo-3-phenyl-4,5-dihydro-[1,2,4]triazol-1-yl)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbethoxyhydrazone du benzoate d'ethyle (70249-85-3) → (4-Amino-5-oxo-3-phenyl-4,5-dihydro-[1,2,4]triazol-1-yl)-acetic acid ethyl ester (96240-14-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / butan-1-ol / 30 h / Heating

2: NaH / 1)DMF, room temp., 30 min, 70-80deg C, 2h 2)70-80 deg C, 8h

With sodium hydride; hydrazine hydrate; In butan-1-ol;

DOI:10.1002/jhet.5570210641

Reference yield:

ethyl bromoacetate (105-36-2) + 4-amino-5-phenyl-2,4-dihydro-[1,2,4]triazol-3-one (57735-10-1) → (4-Amino-5-oxo-3-phenyl-4,5-dihydro-[1,2,4]triazol-1-yl)-acetic acid ethyl ester (96240-14-1)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1)DMF, room temp., 30 min, 70-80deg C, 2h 2)70-80 deg C, 8h;

DOI:10.1002/jhet.5570210641

Reference yield: 72.58%

(4-Amino-5-oxo-3-phenyl-4,5-dihydro-[1,2,4]triazol-1-yl)-acetic acid ethyl ester (96240-14-1) → (4-amino-5-oxo-3-phenyl-4,5-dihydro-[1,2,4]triazol-1-yl)-acetic acid hydrazide (773862-86-5)

Guidance literature:

With hydrazine hydrate; In butan-1-ol; for 4h; Heating;

DOI:10.1016/j.ejmech.2004.06.007

upstream raw materials:

ethyl bromoacetate

4-amino-5-phenyl-2,4-dihydro-[1,2,4]triazol-3-one

carbethoxyhydrazone du benzoate d'ethyle

Downstream raw materials:

(4-{[1-(5-Nitro-furan-2-yl)-meth-(Z)-ylidene]-amino}-5-oxo-3-phenyl-4,5-dihydro-[1,2,4]triazol-1-yl)-acetic acid propyl ester

(4-amino-5-oxo-3-phenyl-4,5-dihydro-[1,2,4]triazol-1-yl)-acetic acid hydrazide

C₁₇H₁₇N₇O₂S