(4S,5R,6S)-2,4-Dimethyl-6-(p-methoxyphenyl)-5-(trimethylsiloxy)-1-hepten-3-one

Base Information

Chemical Name:(4S,5R,6S)-2,4-Dimethyl-6-(p-methoxyphenyl)-5-(trimethylsiloxy)-1-hepten-3-one
CAS No.:147922-83-6
Molecular Formula:C₁₉H₃₀O₃Si
Molecular Weight:334.531
Hs Code.:

Synonyms:(4S,5R,6S)-2,4-Dimethyl-6-(p-methoxyphenyl)-5-(trimethylsiloxy)-1-hepten-3-one

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Chemical Property of (4S,5R,6S)-2,4-Dimethyl-6-(p-methoxyphenyl)-5-(trimethylsiloxy)-1-hepten-3-one

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Technology Process of (4S,5R,6S)-2,4-Dimethyl-6-(p-methoxyphenyl)-5-(trimethylsiloxy)-1-hepten-3-one

There total 5 articles about (4S,5R,6S)-2,4-Dimethyl-6-(p-methoxyphenyl)-5-(trimethylsiloxy)-1-hepten-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: (2S,3R,4S)-4-(p-Methoxyphenyl)-3-(trimethylsiloxy)-2-pentyl endo-2-methylbicyclo<2.2.1>-5-hepten-2-yl ketone

: 147922-83-6
(4S,5R,6S)-2,4-Dimethyl-6-(p-methoxyphenyl)-5-(trimethylsiloxy)-1-hepten-3-one

Guidance literature:: at 500 ℃; under 0.01 Torr;
DOI:10.1021/jo00063a009

Reference yield:

: 111197-94-5
methyl (S)-2-(4-methyoxyphenyl)propionate

: 147922-83-6
(4S,5R,6S)-2,4-Dimethyl-6-(p-methoxyphenyl)-5-(trimethylsiloxy)-1-hepten-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / LiAlH₄

2: 86 percent / Swern oxidation

3: 1.) n-BuLi, 1,1,3,3,3-hexamethyldisilazane / 1.) THF, hexanes, -50 deg C, 3 h, 2.) -38 deg C, 30 min

4: 95 percent / triethylamine, DMSO, DMAP / diethyl ether / 4 h / Ambient temperature

5: 90 percent / 500 °C / 0.01 Torr

With dmap; lithium aluminium tetrahydride; n-butyllithium; dimethyl sulfoxide; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; In diethyl ether;
DOI:10.1021/jo00063a009

Reference yield:

: 93397-63-8
(S)-4-methoxy-β-methylbenzeneethanol

: 147922-83-6
(4S,5R,6S)-2,4-Dimethyl-6-(p-methoxyphenyl)-5-(trimethylsiloxy)-1-hepten-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / Swern oxidation

2: 1.) n-BuLi, 1,1,3,3,3-hexamethyldisilazane / 1.) THF, hexanes, -50 deg C, 3 h, 2.) -38 deg C, 30 min

3: 95 percent / triethylamine, DMSO, DMAP / diethyl ether / 4 h / Ambient temperature

4: 90 percent / 500 °C / 0.01 Torr

With dmap; n-butyllithium; dimethyl sulfoxide; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; In diethyl ether;
DOI:10.1021/jo00063a009