93397-63-8

Basic information

• Product Name: (S)-4-methoxy-β-methylbenzeneethanol
• Synonyms: (S)-4-methoxy-β-methylbenzeneethanol
• CAS NO: 93397-63-8
• Molecular Weight: 166.22
• Mol File: 93397-63-8.mol
• Article Data: 36

Chemical Properties

• CAS DataBase Reference: (S)-4-methoxy-β-methylbenzeneethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-methoxy-β-methylbenzeneethanol(93397-63-8)
• EPA Substance Registry System: (S)-4-methoxy-β-methylbenzeneethanol(93397-63-8)

Safety Data

• Hazardous Substances Data: 93397-63-8(Hazardous Substances Data)

Upstream product

• 252058-33-6 2-(4-methoxyphenyl)propanal 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 2901-41-9 2-(4-methoxyphenyl)ethyl propionate 
• 942-54-1 2-(4-methoxyphenyl)propanoic acid 
• 191725-57-2 1-methoxy-4-(1-methoxyprop-1-en-2-yl)benzene 
• 93397-57-0 Methanesulfonic acid (S)-2-(4-methoxy-phenyl)-1-methyl-2-oxo-ethyl ester 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 124-38-9 carbon dioxide 
• 768-60-5 4-methoxyphenylacetylen 
• 5703-26-4 4-Methoxyphenylacetaldehyde 
• 1612882-19-5 C₁₆H₁₆O₂S₂ 
• 1612882-08-2 C₁₆H₁₄O₂S₂ 
• 140-67-0 Estragole 

Downstream Products

• 6443-75-0 1,2-bis-(4-methoxy-phenyl)-propane 
• 252058-33-6 2-(4-methoxyphenyl)propanal 
• 58282-55-6 2-(3-Acetyl-4-hydroxyphenyl)propyl acetate 
• 1313051-38-5 C₁₂H₁₆O₃ 
• 460323-57-3 Acetic acid (R)-2-(4-methoxy-phenyl)-propyl ester 
• 143590-14-1 (R)-2-(4-methoxyphenyl)propan-1-ol 
• 942-54-1 2-(4-methoxyphenyl)propanoic acid 
• 286967-34-8 2(S)-(4-methoxyphenyl)-1-propanol methanesulfonate 
• 1612882-36-6 C₁₀H₁₃IO 
• 1612882-45-7 C₁₅H₂₀O₅ 
• 1612882-50-4 C₁₃H₁₈O₃ 
• 24470-14-2 (S)-(+)-2-(4'-methoxyphenyl)propanoic acid 

Relevant articles and documents

syn-Selective Michael Reaction of α-Branched Aryl Acetaldehydes with Nitroolefins Promoted by Squaric Amino Acid Derived Bifunctional Br?nsted Bases

Here we describe a direct access to 2,2,3-trisubstituted syn γ-nitroaldehydes by addition of α-branched aryl acetaldehydes to nitroolefins promoted by a cinchona based squaric acid-derived amino acid peptide. Different α-methyl arylacetaldehydes react with β-aromatic and β-alkyl nitroolefins to afford the Michael adducts in high enantioselectivity and syn-selectivity. NMR experiments and DFT calculations predict the reaction to occur through the intermediacy of E-enolate. The interaction between the substrates and the catalyst follows Pápai's model, wherein an intramolecular H-bond interaction in the catalyst between the NH group of one of the tert-leucines and the squaramide oxygen seems to be key for discrimination of the corresponding reaction transition states.

Carbon monoxide and hydrogen (syngas) as a C1-building block for selective catalytic methylation

A catalytic reaction using syngas (CO/H2) as feedstock for the selective β-methylation of alcohols was developed whereby carbon monoxide acts as a C1 source and hydrogen gas as a reducing agent. The overall transformation occurs through an intricate network of metal-catalyzed and base-mediated reactions. The molecular complex [Mn(CO)2Br[HN(C2H4PiPr2)2]]1comprising earth-abundant manganese acts as the metal component in the catalytic system enabling the generation of formaldehyde from syngas in a synthetically useful reaction. This new syngas conversion opens pathways to install methyl branches at sp3carbon centers utilizing renewable feedstocks and energy for the synthesis of biologically active compounds, fine chemicals, and advanced biofuels.

Ru-Catalyzed Selective Catalytic Methylation and Methylenation Reaction Employing Methanol as the C1 Source

Methanol can be employed as a green and sustainable methylating agent to form C-C and C-N bonds via borrowing hydrogen (BH) methodology. Herein we explored the activity of the acridine-derived SNS-Ru pincer for the activation of methanol to apply it as a C1 building block in different reactions. Our catalytic system shows great success toward the β-C(sp3)-methylation reaction of 2-phenylethanols to provide good to excellent yields of the methylated products. We investigated the mechanistic details, kinetic progress, and temperature-dependent product distribution, which revealed the slow and steady generation of in situ formed aldehyde, is the key factor to get the higher yield of the β-methylated product. To establish the environmental benefit of this reaction, green chemistry metrics are calculated. Furthermore, dimerization of 2-naphthol via methylene linkage and formation of N-methylation of amine are also described in this study, which offers a wide range of substrate scope with a good to excellent yield.