N-[2-(DIMETHYLAMINO)ETHYL]BENZENE-1,2-DIAMINE

Base Information

• Chemical Name: N-[2-(DIMETHYLAMINO)ETHYL]BENZENE-1,2-DIAMINE
• CAS No.: 78156-03-3
• Molecular Formula: C10H17 N3
• Molecular Weight: 179.265
• Hs Code.: 2921590090
• Mol file: 78156-03-3.mol

Synonyms:1,2-Benzenediamine,N-[2-(dimethylamino)ethyl]- (9CI)

Chemical Property of N-[2-(DIMETHYLAMINO)ETHYL]BENZENE-1,2-DIAMINE

Chemical Property:

• Vapor Pressure: 0.000362mmHg at 25°C
• Melting Point: 54-55 °C
• Refractive Index: 1.603
• Boiling Point: 318.4°C at 760 mmHg
• PKA: 9.15±0.28(Predicted)
• Flash Point: 146.4°C
• PSA: 41.29000
• Density: 1.067g/cm³
• LogP: 1.89650

Purity/Quality:

99% ^*data from raw suppliers

N-(2-DIMETHYLAMINO-ETHYL)-BENZENE-1,2-DIAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[2-(DIMETHYLAMINO)ETHYL]BENZENE-1,2-DIAMINE

There total 4 articles about N-[2-(DIMETHYLAMINO)ETHYL]BENZENE-1,2-DIAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N1,N1-dimethyl-N2-(2-nitrophenyl)ethane-1,2-diamine (25238-55-5) → N-(2-dimethylamino-ethyl)-benzene-1,2-diamine (78156-03-3)

Guidance literature:

With nickel; hydrazine; In methanol; at 20 ℃;

Reference yield:

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → N-(2-dimethylamino-ethyl)-benzene-1,2-diamine (78156-03-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 12 h / 30 °C / Inert atmosphere

2: acetic acid; zinc / 1 h / 0 - 20 °C

With acetic acid; zinc; In tetrahydrofuran;

DOI:10.1016/j.ejmech.2015.01.024

Reference yield:

2-Chloronitrobenzene (88-73-3) → N-(2-dimethylamino-ethyl)-benzene-1,2-diamine (78156-03-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 24 h / Heating

2: H₂ / 5percent Pd/C / ethanol

With hydrogen; palladium on activated charcoal; In ethanol;

upstream raw materials:

N¹,N¹-dimethyl-N²-(2-nitrophenyl)ethane-1,2-diamine

2-Chloronitrobenzene

2-nitrophenyl bromide

ortho-nitrofluorobenzene

Downstream raw materials:

4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-carboxylic acid {(R)-2-(4-amino-3,5-dibromo-phenyl)-1-[2-(2-dimethylamino-ethylamino)-phenylcarbamoyl]-ethyl}-amide

4-fenil-1,3-diidro-1-<(dimetilammino)etil>-2H-1,5-benzodiazepin-2-one

1-(2-dimethylamino-ethyl)-3-phenyl-quinoxalinium; chloride-hydrochloride

Refernces

• 1、 -. "1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME". Page/Page column 117-118. . Retrieved 2020/12/11.
• 2、 Bressi, Jerome C.,Jong, Ron de,Wu, Yiqin,Jennings, Andy J.,Brown, Jason W.,O'Connell, Shawn,Tari, Leslie W.,Skene, Robert J.,Vu, Phong,Navre, Marc,Cao, Xiaodong,Gangloff, Anthony R.. "Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity". scheme or table. p. 3138 - 3141. Retrieved 2010/09/03.