25238-55-5

Basic information

• Product Name: 1,2-Ethanediamine, N,N-dimethyl-N'-(2-nitrophenyl)-
• CAS NO: 25238-55-5
• Molecular Formula: C10H15N3O2
• Molecular Weight: 209.248
• Mol File: 25238-55-5.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 1,2-Ethanediamine, N,N-dimethyl-N'-(2-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Ethanediamine, N,N-dimethyl-N'-(2-nitrophenyl)-(25238-55-5)
• EPA Substance Registry System: 1,2-Ethanediamine, N,N-dimethyl-N'-(2-nitrophenyl)-(25238-55-5)

Safety Data

• Hazardous Substances Data: 25238-55-5(Hazardous Substances Data)

Upstream product

• 70384-51-9 Tris(3,6-dioxaheptyl)amine 
• 108-00-9 N,N-dimethylethylenediamine 
• 1493-27-2 ortho-nitrofluorobenzene 
• 88-73-3 2-Chloronitrobenzene 
• 577-19-5 2-nitrophenyl bromide 

Downstream Products

• 126610-67-1 4-fenil-1,3-diidro-1-<(dimetilammino)etil>-2H-1,5-benzodiazepin-2-one 
• 131637-68-8 N-(2-aminophenyl)-2-(dimethylamino)ethylamine hydrochloride 
• 78156-03-3 N-(2-dimethylamino-ethyl)-benzene-1,2-diamine 

Relevant articles and documents

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1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to 1,3,4-oxadiazole derivative compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, a use thereof in preparation of a medicament, a pharmaceutical composition comprising the same, a therapeutic method using the composition, and a method for preparing the same, and the 1,3,4-oxadiazole derivative compounds are represented by a following chemical formula (I).

Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity

A series of N-hydroxy-3-[3-(1-substituted-1H-benzoimidazol-2-yl)-phenyl]-acrylamides (5a-5ab) and N-hydroxy-3-[3-(1,4,5-trisubstituted-1H-imidazol-2-yl)-phenyl]-acrylamides (12a-s) were designed, synthesized, and found to be nanomolar inhibitors of human histone deacetylases. Multiple compounds bearing an N1-piperidine demonstrate EC50s of 20-100 nM in human A549, HL60, and PC3 cells, in vitro and in vivo hyperacetylation of histones H3 and H4, and induction of p21waf. Compound 5x displays efficacy in human tumor xenograft models.