N₁-[(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-methylalaninamide

Base Information

• Chemical Name: N₁-[(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-methylalaninamide
• CAS No.: 1361330-30-4
• Molecular Formula: C₂₆H₂₈ClN₅O₄S
• Molecular Weight: 542.058

Synonyms:N₁-[(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-methylalaninamide

Chemical Property of N₁-[(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-methylalaninamide

Chemical Property:

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Technology Process of N₁-[(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-methylalaninamide

There total 5 articles about N₁-[(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-methylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C31H36ClN5O6S → N1-[(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-methylalaninamide (1361330-30-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 1h;

Reference yield:

3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}-benzonitrile (1240518-02-8) → N1-[(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-methylalaninamide (1361330-30-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 1 h / 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h

2.2: 0.5 h / 20 °C

3.1: pyridine / dichloromethane / 1 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h

With pyridine; lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

2-fluoro-6-methoxybenzonitrile (94088-46-7) → N1-[(3-{[3-{[(3-chlorophenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-methylalaninamide (1361330-30-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: hydrazine hydrate / butan-1-ol / 18 h / Reflux; Inert atmosphere

2.1: potassium hydroxide / dimethyl sulfoxide / 0.33 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 1 h / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h

4.2: 0.5 h / 20 °C

5.1: pyridine / dichloromethane / 1 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 1 h

With pyridine; lithium aluminium tetrahydride; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; butan-1-ol;

upstream raw materials:

2-fluoro-6-methoxybenzonitrile

4-(methyloxy)-1H-indazol-3-amine

3-{[3-amino-4-(methyloxy)-1H-indazol-1-yl]methyl}-benzonitrile

1-{[3-(aminomethyl)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-amine

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