4-{4-[(R)-1-(N-isobutyl-1-phenylmethylsulfonamido)-ethyl]-phenyl}-piperazine-1-sulfonic acid N,N-dimethylamide

Base Information

Chemical Name:4-{4-[(R)-1-(N-isobutyl-1-phenylmethylsulfonamido)-ethyl]-phenyl}-piperazine-1-sulfonic acid N,N-dimethylamide
CAS No.:1445902-12-4
Molecular Formula:C₂₅H₃₈N₄O₄S₂
Molecular Weight:522.733
Hs Code.:

Synonyms:4-{4-[(R)-1-(N-isobutyl-1-phenylmethylsulfonamido)-ethyl]-phenyl}-piperazine-1-sulfonic acid N,N-dimethylamide

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Chemical Property of 4-{4-[(R)-1-(N-isobutyl-1-phenylmethylsulfonamido)-ethyl]-phenyl}-piperazine-1-sulfonic acid N,N-dimethylamide

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Technology Process of 4-{4-[(R)-1-(N-isobutyl-1-phenylmethylsulfonamido)-ethyl]-phenyl}-piperazine-1-sulfonic acid N,N-dimethylamide

There total 4 articles about 4-{4-[(R)-1-(N-isobutyl-1-phenylmethylsulfonamido)-ethyl]-phenyl}-piperazine-1-sulfonic acid N,N-dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98961-97-8
piperazine-1-sulfonic acid dimethylamide

: 1445720-42-2
(R)-N-(1-(4-bromophenyl)ethyl)-N-isobutyl(phenyl)methanesulfonamide

: 1445902-12-4
4-{4-[(R)-1-(N-isobutyl-1-phenylmethylsulfonamido)-ethyl]-phenyl}-piperazine-1-sulfonic acid N,N-dimethylamide

Guidance literature:: With chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate; ruphos; In 1,4-dioxane; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1939-99-7
benzenesulfonyl chloride

: 1445902-12-4
4-{4-[(R)-1-(N-isobutyl-1-phenylmethylsulfonamido)-ethyl]-phenyl}-piperazine-1-sulfonic acid N,N-dimethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 1 h / 0 - 10 °C

2: caesium carbonate / N,N-dimethyl-formamide / 20 h / 0 - 80 °C

3: chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate; ruphos / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

With pyridine; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; caesium carbonate; sodium t-butanolate; ruphos; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 24358-62-1,27298-97-1,45791-36-4,64313-06-0
(R)-1-(4-bromophenyl)ethylamine

: 1445902-12-4
4-{4-[(R)-1-(N-isobutyl-1-phenylmethylsulfonamido)-ethyl]-phenyl}-piperazine-1-sulfonic acid N,N-dimethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 1 h / 0 - 10 °C

2: caesium carbonate / N,N-dimethyl-formamide / 20 h / 0 - 80 °C

3: chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate; ruphos / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere

With pyridine; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; caesium carbonate; sodium t-butanolate; ruphos; In 1,4-dioxane; N,N-dimethyl-formamide;