6-N-Benzoyl-9-<2-deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine

Base Information

• Chemical Name: 6-N-Benzoyl-9-<2-deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine
• CAS No.: 141690-78-0
• Molecular Formula: C₃₈H₃₅N₅O₇S
• Molecular Weight: 705.791

Synonyms:6-N-Benzoyl-9-<2-deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine

Chemical Property of 6-N-Benzoyl-9-<2-deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 6-N-Benzoyl-9-<2-deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine

There total 2 articles about 6-N-Benzoyl-9-<2-deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

benzoyl chloride (98-88-4) + 9-<2-Deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine (108895-41-6) → 6-N-Benzoyl-9-<2-deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine (141690-78-0) + 6-N,N-Dibenzoyl-9-<2-deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine (141690-79-1)

Guidance literature:

With pyridine; at 0 ℃; for 4h;

DOI:10.1016/S0040-4020(01)88532-X

Reference yield:

9-<5-O-(monomethoxytrityl)-2-deoxy-β-D-threo-pentofuranosyl>adenine (108895-39-2) → 6-N-Benzoyl-9-<2-deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine (141690-78-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / pyridine / 4 °C

2: 5 percent / pyridine / 4 h / 0 °C

With pyridine;

DOI:10.1016/S0040-4020(01)88532-X

Reference yield:

Methanesulfonic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester (141690-78-0) → 6-N-benzoyl-3'-O-mesyl-2'-deoxyadenosine (110143-01-6)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; chloroform; for 0.333333h; Yield given;

DOI:10.1021/jm00394a034

upstream raw materials:

benzoyl chloride

9-<2-Deoxy-3-O-methanesulphonyl-5-O-(4-monomethoxytrityl)-β-D-threo-pentofuranosyl>adenine

9-<5-O-(monomethoxytrityl)-2-deoxy-β-D-threo-pentofuranosyl>adenine

Downstream raw materials:

6-N-benzoyl-3'-O-mesyl-2'-deoxyadenosine

9-(3-azido-2,3-dideoxy-β-D-threo-pentofuranosyl)-N-benzoyladenine

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