2-(allylamino)-4-(benzyloxy)-7-chloropyrido[2,3-d]pyrimidine-6-carbaldehyde

Base Information

• Chemical Name: 2-(allylamino)-4-(benzyloxy)-7-chloropyrido[2,3-d]pyrimidine-6-carbaldehyde
• CAS No.: 1253390-59-8
• Molecular Formula: C₁₈H₁₅ClN₄O₂
• Molecular Weight: 354.796

Synonyms:2-(allylamino)-4-(benzyloxy)-7-chloropyrido[2,3-d]pyrimidine-6-carbaldehyde

Chemical Property of 2-(allylamino)-4-(benzyloxy)-7-chloropyrido[2,3-d]pyrimidine-6-carbaldehyde

Chemical Property:

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Technology Process of 2-(allylamino)-4-(benzyloxy)-7-chloropyrido[2,3-d]pyrimidine-6-carbaldehyde

There total 2 articles about 2-(allylamino)-4-(benzyloxy)-7-chloropyrido[2,3-d]pyrimidine-6-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(2-(allylamino)-4-(benzyloxy)-7-chloropyrido[2,3-d]pyrimidin-6-yl)methanol (1253390-61-2) → 2-(allylamino)-4-(benzyloxy)-7-chloropyrido[2,3-d]pyrimidine-6-carbaldehyde (1253390-59-8)

Guidance literature:

With pyridinium chlorochromate; In chloroform; at 20 ℃; Inert atmosphere;

DOI:10.1021/jo101194v

Reference yield: 50.0%

2-(allylamino)-4-(benzyloxy)-7-chloropyrido[2,3-d]pyrimidine-6-carbonitrile (1253390-57-6) → 2-(allylamino)-4-(benzyloxy)-7-chloropyrido[2,3-d]pyrimidine-6-carbaldehyde (1253390-59-8)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at 20 ℃; for 3.5h; Inert atmosphere;

DOI:10.1021/jo101194v

Reference yield: 73.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-(allylamino)-4-(benzyloxy)-7-chloropyrido[2,3-d]pyrimidine-6-carbaldehyde (1253390-59-8) → tert-butyl allyl-(4-(benzyloxy)-7-chloro-6-formylpyrido[2,3-d]pyrimidin-2-yl)carbamate (1253390-67-8)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1021/jo101194v

upstream raw materials:

2-(allylamino)-4-(benzyloxy)-7-chloropyrido[2,3-d]pyrimidine-6-carbonitrile

(2-(allylamino)-4-(benzyloxy)-7-chloropyrido[2,3-d]pyrimidin-6-yl)methanol

Downstream raw materials:

tert-butyl allyl-(4-(benzyloxy)-7-chloro-6-formylpyrido[2,3-d]pyrimidin-2-yl)carbamate

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