tert-butyl allyl-(4-(benzyloxy)-7-chloro-6-formylpyrido[2,3-d]pyrimidin-2-yl)carbamate

Base Information

• Chemical Name: tert-butyl allyl-(4-(benzyloxy)-7-chloro-6-formylpyrido[2,3-d]pyrimidin-2-yl)carbamate
• CAS No.: 1253390-67-8
• Molecular Formula: C₂₃H₂₃ClN₄O₄
• Molecular Weight: 454.913
• Mol file: 1253390-67-8.mol

Synonyms:tert-butyl allyl-(4-(benzyloxy)-7-chloro-6-formylpyrido[2,3-d]pyrimidin-2-yl)carbamate

Chemical Property of tert-butyl allyl-(4-(benzyloxy)-7-chloro-6-formylpyrido[2,3-d]pyrimidin-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl allyl-(4-(benzyloxy)-7-chloro-6-formylpyrido[2,3-d]pyrimidin-2-yl)carbamate

There total 1 articles about tert-butyl allyl-(4-(benzyloxy)-7-chloro-6-formylpyrido[2,3-d]pyrimidin-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-(allylamino)-4-(benzyloxy)-7-chloropyrido[2,3-d]pyrimidine-6-carbaldehyde (1253390-59-8) → tert-butyl allyl-(4-(benzyloxy)-7-chloro-6-formylpyrido[2,3-d]pyrimidin-2-yl)carbamate (1253390-67-8)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1021/jo101194v

Reference yield: 52.0%

tert-butyl allyl-(4-(benzyloxy)-7-chloro-6-formylpyrido[2,3-d]pyrimidin-2-yl)carbamate (1253390-67-8) → tert-butyl allyl(4-(benzyloxy)-6-formyl-7-hydroxypyrido[2,3-d]pyrimidin-2-yl)carbamate (1253390-80-5) + tert-butyl allyl-(7-amino-4-(benzyloxy)-6-formylpyrido[2,3-d]pyrimidin-2-yl)carbamate (1253390-69-0)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; ammonia; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 13h; Inert atmosphere;

DOI:10.1021/jo101194v

Reference yield: 50.0%

1,4-diaza-bicyclo[2.2.2]octane (280-57-9,88935-43-7) + tert-butyl allyl-(4-(benzyloxy)-7-chloro-6-formylpyrido[2,3-d]pyrimidin-2-yl)carbamate (1253390-67-8) → tert-butyl allyl-(7-amino-4-(benzyloxy)-6-formylpyrido[2,3-d]pyrimidin-2-yl)carbamate (1253390-69-0) + tert-butyl allyl(4-(benzyloxy)-7-(4-(2-chloroethyl)piperazin-1-yl)-6-formylpyrido[2,3-d]pyrimidin-2-yl)carbamate (1253390-82-7)

Guidance literature:

With ammonia; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jo101194v

upstream raw materials:

di-tert-butyl dicarbonate

2-(allylamino)-4-(benzyloxy)-7-chloropyrido[2,3-d]pyrimidine-6-carbaldehyde

Downstream raw materials:

tert-butyl allyl-(7-amino-4-(benzyloxy)-6-formylpyrido[2,3-d]pyrimidin-2-yl)carbamate

tert-butyl allyl(4-(benzyloxy)-7-(4-(2-chloroethyl)piperazin-1-yl)-6-formylpyrido[2,3-d]pyrimidin-2-yl)carbamate

1-(2-(allyl(tert-butoxycarbonyl)amino)-4-(benzyloxy)-6-formylpyrido[2,3-d]pyrimidin-7-yl)-4-methoxypyridinium chloride

N-(1-(2-(allyl(tert-butoxycarbonyl)amino)-4-(benzyloxy)-6-formylpyrido[2,3-d]pyrimidin-7-yl)pyridin-4(1H)-ylidene)-N-methylmethanaminium chloride