(R)-1-O-acetyl-2-O-benzyl-3-O-tert-butyldimethylsilylglycerol

Base Information

• Chemical Name: (R)-1-O-acetyl-2-O-benzyl-3-O-tert-butyldimethylsilylglycerol
• CAS No.: 132928-93-9
• Molecular Formula: C₁₈H₃₀O₄Si
• Molecular Weight: 338.519
• Mol file: 132928-93-9.mol

Synonyms:(R)-1-O-acetyl-2-O-benzyl-3-O-tert-butyldimethylsilylglycerol

Chemical Property of (R)-1-O-acetyl-2-O-benzyl-3-O-tert-butyldimethylsilylglycerol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-O-acetyl-2-O-benzyl-3-O-tert-butyldimethylsilylglycerol

There total 1 articles about (R)-1-O-acetyl-2-O-benzyl-3-O-tert-butyldimethylsilylglycerol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(S)-2-(benzyloxy)-3-hydroxypropyl acetate (109429-01-8) + tert-butyldimethylsilyl chloride (18162-48-6) → (R)-1-O-acetyl-2-O-benzyl-3-O-tert-butyldimethylsilylglycerol (132928-93-9)

Guidance literature:

With triethylamine; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1248/cpb.38.3347

Reference yield: 92.7%

(R)-1-O-acetyl-2-O-benzyl-3-O-tert-butyldimethylsilylglycerol (132928-93-9) → (R)-2-O-benzyl-1-O-tert-butyldimethylsilylglycerol (132928-94-0)

Guidance literature:

With potassium hydroxide; In methanol; for 15h; Ambient temperature;

DOI:10.1248/cpb.38.3347

Reference yield:

(R)-1-O-acetyl-2-O-benzyl-3-O-tert-butyldimethylsilylglycerol (132928-93-9) → (R)-2-O-benzyl-3-O-tert-butyldimethylsilyl-1-O-glycerol (132928-95-1,132928-96-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 92.7 percent / KOH / methanol / 15 h / Ambient temperature

2: 8.8 percent / Hg(CN)2, HgBr₂, molecular sieves 4A / CH₂Cl₂ / 96 h / Ambient temperature

With potassium hydroxide; 4 A molecular sieve; mercury(II) cyanide; mercury dibromide; In methanol; dichloromethane;

DOI:10.1248/cpb.38.3347

upstream raw materials:

(S)-2-(benzyloxy)-3-hydroxypropyl acetate

tert-butyldimethylsilyl chloride

Downstream raw materials:

(R)-2-O-benzyl-1-O-tert-butyldimethylsilylglycerol

(R)-2-O-benzyl-3-O-tert-butyldimethylsilyl-1-O-glycerol

(R)-2-O-benzyl-3-O-tert-butyldimethylsilyl-1-O-glycerol