7-benzyloxy-4-(4-methyl-3,5-trimethoxyphenyl)-3-isocoumarincarboxylic acid

Base Information

Chemical Name:7-benzyloxy-4-(4-methyl-3,5-trimethoxyphenyl)-3-isocoumarincarboxylic acid
CAS No.:212501-60-5
Molecular Formula:C₂₆H₂₂O₇
Molecular Weight:446.456
Hs Code.:

Synonyms:7-benzyloxy-4-(4-methyl-3,5-trimethoxyphenyl)-3-isocoumarincarboxylic acid

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Chemical Property of 7-benzyloxy-4-(4-methyl-3,5-trimethoxyphenyl)-3-isocoumarincarboxylic acid

Chemical Property:

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Technology Process of 7-benzyloxy-4-(4-methyl-3,5-trimethoxyphenyl)-3-isocoumarincarboxylic acid

There total 6 articles about 7-benzyloxy-4-(4-methyl-3,5-trimethoxyphenyl)-3-isocoumarincarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[5-benzyloxy-2-(3,5-dimethoxy-4-methyl-benzoyl)-benzoyloxy]-malonic acid di-tert-butyl ester

: 212501-60-5
7-benzyloxy-4-(4-methyl-3,5-trimethoxyphenyl)-3-isocoumarincarboxylic acid

Guidance literature:: 2-[5-benzyloxy-2-(3,5-dimethoxy-4-methyl-benzoyl)-benzoyloxy]-malonic acid di-tert-butyl ester; With hydrogenchloride; In ethyl acetate; at 20 ℃;

With acetic acid; In 1,4-dioxane; for 6h; Further stages.; Heating;
DOI:10.1021/jm000558h

Reference yield:

: 1011-27-4
3,5-dimethoxy-4-methylbenzaldehyde

: 212501-60-5
7-benzyloxy-4-(4-methyl-3,5-trimethoxyphenyl)-3-isocoumarincarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

1.2: tetrahydrofuran / 0.5 h / -78 °C

2.1: TFA / CH₂Cl₂; H₂O / 2 h / 20 °C

3.1: resorcinol; acetate buffer; NaClO₂ / dioxane; H₂O / 20 °C / pH 3.8

4.1: K₂CO₃ / dimethylformamide / 20 °C

5.1: 4 N HCl / ethyl acetate / 20 °C

5.2: AcOH / dioxane / 6 h / Heating

With hydrogenchloride; sodium chlorite; n-butyllithium; acetate buffer; potassium carbonate; trifluoroacetic acid; recorcinol; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm000558h

Reference yield:

: 81418-49-7
5-(benzyloxy)-2-bromobenzaldehyde dimethylacetal

: 212501-60-5
7-benzyloxy-4-(4-methyl-3,5-trimethoxyphenyl)-3-isocoumarincarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

1.2: tetrahydrofuran / 0.5 h / -78 °C

2.1: TFA / CH₂Cl₂; H₂O / 2 h / 20 °C

3.1: resorcinol; acetate buffer; NaClO₂ / dioxane; H₂O / 20 °C / pH 3.8

4.1: K₂CO₃ / dimethylformamide / 20 °C

5.1: 4 N HCl / ethyl acetate / 20 °C

5.2: AcOH / dioxane / 6 h / Heating

With hydrogenchloride; sodium chlorite; n-butyllithium; acetate buffer; potassium carbonate; trifluoroacetic acid; recorcinol; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm000558h