3,5-Bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid (2S,3R,4R,5S,6R)-2-allyloxy-5-hydroxy-6-hydroxymethyl-3-(2,2,2-trichloro-ethoxycarbonylamino)-tetrahydro-pyran-4-yl ester

Base Information

Chemical Name:3,5-Bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid (2S,3R,4R,5S,6R)-2-allyloxy-5-hydroxy-6-hydroxymethyl-3-(2,2,2-trichloro-ethoxycarbonylamino)-tetrahydro-pyran-4-yl ester
CAS No.:873848-09-0
Molecular Formula:C₃₇H₅₈Cl₃NO₁₈
Molecular Weight:911.222
Hs Code.:

3,5-Bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid (2S,3R,4R,5S,6R)-2-allyloxy-5-hydroxy-6-hydroxymethyl-3-(2,2,2-trichloro-ethoxycarbonylamino)-tetrahydro-pyran-4-yl ester

Synonyms:3,5-Bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid (2S,3R,4R,5S,6R)-2-allyloxy-5-hydroxy-6-hydroxymethyl-3-(2,2,2-trichloro-ethoxycarbonylamino)-tetrahydro-pyran-4-yl ester

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Chemical Property of 3,5-Bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid (2S,3R,4R,5S,6R)-2-allyloxy-5-hydroxy-6-hydroxymethyl-3-(2,2,2-trichloro-ethoxycarbonylamino)-tetrahydro-pyran-4-yl ester

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Technology Process of 3,5-Bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid (2S,3R,4R,5S,6R)-2-allyloxy-5-hydroxy-6-hydroxymethyl-3-(2,2,2-trichloro-ethoxycarbonylamino)-tetrahydro-pyran-4-yl ester

There total 7 articles about 3,5-Bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid (2S,3R,4R,5S,6R)-2-allyloxy-5-hydroxy-6-hydroxymethyl-3-(2,2,2-trichloro-ethoxycarbonylamino)-tetrahydro-pyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 873848-08-9
3,5-Bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid (2R,4aR,6S,7R,8R,8aS)-6-allyloxy-2-phenyl-7-(2,2,2-trichloro-ethoxycarbonylamino)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester

: 873848-09-0
3,5-Bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid (2S,3R,4R,5S,6R)-2-allyloxy-5-hydroxy-6-hydroxymethyl-3-(2,2,2-trichloro-ethoxycarbonylamino)-tetrahydro-pyran-4-yl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1055/s-2005-872269

Reference yield:

: 873848-07-8
3,5-bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid

: 873848-09-0
3,5-Bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid (2S,3R,4R,5S,6R)-2-allyloxy-5-hydroxy-6-hydroxymethyl-3-(2,2,2-trichloro-ethoxycarbonylamino)-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / DIC; DMAP / CH₂Cl₂ / 20 °C

2: 84 percent / aq. TFA / CH₂Cl₂

With dmap; dacarbazine; trifluoroacetic acid; In dichloromethane;
DOI:10.1055/s-2005-872269

Reference yield:

: 112-35-6,95507-80-5
triethylene glucol monomethyl ether

: 873848-09-0
3,5-Bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid (2S,3R,4R,5S,6R)-2-allyloxy-5-hydroxy-6-hydroxymethyl-3-(2,2,2-trichloro-ethoxycarbonylamino)-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / Et₃N / CH₂Cl₂

2: 78 percent / NaH / dimethylformamide

3: 100 percent / Et₃N / CH₂Cl₂

4: NaI; K₂CO₃ / 50 °C

5: aq. NaOH / dimethylformamide

6: 93 percent / DIC; DMAP / CH₂Cl₂ / 20 °C

7: 84 percent / aq. TFA / CH₂Cl₂

With dmap; sodium hydroxide; sodium hydride; potassium carbonate; dacarbazine; triethylamine; trifluoroacetic acid; sodium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-2005-872269