873848-07-8

Upstream product

• 112-35-6 triethylene glucol monomethyl ether 
• 62921-76-0 2,5,8,11-tetraoxatridecan-13-ol tosylate 
• 2150-44-9 1-carbomethoxy-3,5-dihydroxybenzene 
• 110429-45-3 1-{2-[2-(2-bromo-ethoxy)-ethoxy]-ethoxy}-2-methoxy-ethane 
• 130955-37-2 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethyl) methanesulfonate 
• 74654-05-0 8-methoxy-1-(methylsulfonyl)oxy-3,6-dioxaoctane 
• 23783-42-8 tetraethylene glycol monomethyl ether 

Downstream Products

• 873848-08-9 3,5-Bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid (2R,4aR,6S,7R,8R,8aS)-6-allyloxy-2-phenyl-7-(2,2,2-trichloro-ethoxycarbonylamino)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 
• 873848-23-8 C₆₆H₈₃Cl₃N₂O₂₈ 
• 873848-27-2 C₆₀H₈₅ClN₄O₂₈ 
• 873848-14-7 C₆₁H₈₅Cl₃N₂O₂₆ 
• 873848-28-3 acetic acid 4,5-diacetoxy-6-acetoxymethyl-2-{6-allyloxy-5-allyloxycarbonylamino-2-[3,5-bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzyloxycarbonyloxymethyl]-4-hydroxy-tetrahydro-pyran-3-yloxy}-tetrahydro-pyran-3-yl ester 
• 873848-26-1 Carbonic acid (2R,3S,4R,5R,6S)-6-allyloxy-5-allyloxycarbonylamino-4-(4-azido-3-chloro-benzyloxy)-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester 3,5-bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzyl ester 
• 873848-22-7 C₅₁H₆₅NO₁₉ 
• 873848-13-6 N-[4-((2S,3R,4S,5R,6R)-4-Benzyloxy-5-hydroxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yloxymethyl)-phenyl]-3,5-bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzamide 
• 873848-09-0 3,5-Bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid (2S,3R,4R,5S,6R)-2-allyloxy-5-hydroxy-6-hydroxymethyl-3-(2,2,2-trichloro-ethoxycarbonylamino)-tetrahydro-pyran-4-yl ester 
• 873848-25-0 carbonic acid 3,5-bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzyl ester 4-nitro-phenyl ester 
• 720681-04-9 [3,5-bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-phenyl]-methanol 
• 873848-21-6 C₅₈H₆₉NO₁₉ 
• 873848-12-5 N-[4-((2R,4aR,6S,7R,8S,8aR)-8-Benzyloxy-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yloxymethyl)-phenyl]-3,5-bis-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzamide 

Relevant academic research and scientific papers

Novel Macrocyclic Peptidomimetics Targeting the Polo-Box Domain of Polo-Like Kinase 1

The polo-box domain (PBD) of Plk1 is a promising target for cancer therapeutics. We designed and synthesized novel phosphorylated macrocyclic peptidomimetics targeting PBD based on acyclic phosphopeptide PMQSpTPL. The inhibitory activities of 16e on Plk1-PBD is >30-fold higher than those of PMQSpTPL. Both 16a and 16e possess excellent selectivity for Plk1-PBD over Plk2/3-PBD. Analysis of the cocrystal structure of Plk1-PBD in complex with 16a reveals that the 3-(trifluoromethyl)benzoyl group in 16a interacts with Arg516 through a π-stacking interaction. This π-stacking interaction, which has not been reported previously, provides insight into the design of novel and potent Plk1-PBD inhibitors. Furthermore, 16h, a PEGlyated macrocyclic phosphopeptide derivative, induces Plk1 delocalization and mitotic failure in HeLa cells. Also, the number of phospho-H3-positive cells in a zebrafish embryo increases in proportion to the amount of 16a. Collectively, the novel macrocyclic peptidomimetics should serve as valuable templates for the design of potent and novel Plk1-PBD inhibitors.

Templated Formation of Luminescent Virus-like Particles by Tailor-Made Pt(II) Amphiphiles

Virus-like particles (VLPs) have been created from luminescent Pt(II) complex amphiphiles, able to form supramolecular structures in water solutions, that can be encapsulated or act as templates of cowpea chlorotic mottle virus capsid proteins. By virtue

Oligosaccharide synthesis by affinity separation based on molecular recognition between podand ether and ammonium ion

We previously reported a new synthetic methodology termed 'synthesis based on affinity separation' (SAS) in which the desired tagged compound was separated from the reaction mixture by solid-phase extraction using specific molecular recognition of the tag. The interaction between a crown ether tag and polymer-supported ammonium ion was initially employed for SAS. In the present study, a new SAS method using a podand-type tag, a pseudo-benzo-31-crown-10 structure, was elaborated for oligosaccharide synthesis. The podand tag was much easier to synthesize than the corresponding crown ether. The podand moiety was attached to the monosaccharide residue via appropriate linkers. After glycosylation of the tagged monosaccharide with a glycosyl donor, the reaction mixture was subjected to the affinity separation. The desired compounds possessing the podand tag were effectively separated by the affinity between the podand and the ammonium ion. Continuous flow synthesis by integration of a microreactor and the present SAS system was applied for high throughput oligosaccharide synthesis. Georg Thieme Verlag Stuttgart.