1-(2-Hydroxyethoxymethyl)-5-(trifluoromethyl)pyrimidine-2,4-dione

Base Information

Chemical Name:1-(2-Hydroxyethoxymethyl)-5-(trifluoromethyl)pyrimidine-2,4-dione
CAS No.:78097-09-3
Molecular Formula:C₈H₉F₃N₂O₄
Molecular Weight:254.166
Hs Code.:2933599090
ChEMBL ID:CHEMBL165179
DSSTox Substance ID:DTXSID90468433
Wikidata:Q82295624
Mol file:78097-09-3.mol

Synonyms:78097-09-3;1-(2-hydroxyethoxymethyl)-5-(trifluoromethyl)pyrimidine-2,4-dione;1-((2-Hydroxyethoxy)methyl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione;CHEMBL165179;DTXSID90468433;1-(2-Hydroxy-ethoxymethyl)-5-trifluoromethyl-1H-pyrimidine-2,4-dione;1-(2-Hydroxy-ethoxymethyl)-5-triflu;AKOS015965990;AG-H-13296;1-[(2-Hydroxyethoxy)methyl]-5-(trifluoromethyl)uracil

Suppliers and Price of 1-(2-Hydroxyethoxymethyl)-5-(trifluoromethyl)pyrimidine-2,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-(2-HYDROXY-ETHOXYMETHYL)-5-TRIFLUOROMETHYL-1H-PYRIMIDINE-2,4-DIONE 95.00%
5MG
$ 495.64

Total 3 raw suppliers

Chemical Property of 1-(2-Hydroxyethoxymethyl)-5-(trifluoromethyl)pyrimidine-2,4-dione

Chemical Property:

PSA：84.32000
LogP:-0.47820
XLogP3:-0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:254.05144126
Heavy Atom Count:17
Complexity:353

Purity/Quality:

99% ^*data from raw suppliers

1-(2-HYDROXY-ETHOXYMETHYL)-5-TRIFLUOROMETHYL-1H-PYRIMIDINE-2,4-DIONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=O)NC(=O)N1COCCO)C(F)(F)F

Technology Process of 1-(2-Hydroxyethoxymethyl)-5-(trifluoromethyl)pyrimidine-2,4-dione

There total 3 articles about 1-(2-Hydroxyethoxymethyl)-5-(trifluoromethyl)pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 78097-07-1
1-<(2-acetoxyethoxy)methyl>-5-(trifluoromethyl)uracil

: 78097-09-3
1-<(2-hydroxyethoxy)methyl>-5-(trifluoromethyl)uracil

Guidance literature:: With sodium methylate; In methanol; for 0.5h; Heating;
DOI:10.1021/jm00138a022

Reference yield:

: 54-20-6
5-trifluoromethyluracil

: 78097-09-3
1-<(2-hydroxyethoxy)methyl>-5-(trifluoromethyl)uracil

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 20 °C

2: 320 mg / KI; chlorotrimethylsilane / 16 h / 25 °C

With chloro-trimethyl-silane; potassium iodide; In acetonitrile;
DOI:10.1021/jm058271d