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1,3-Dioxolane Manufacturer/High quality/Best price/In stock
Cas No: 646-06-0
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality 1,3-Dioxolane supplier in China
Cas No: 646-06-0
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1,3-Dioxolane
Cas No: 646-06-0
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1,3-Dioxolane CAS#646-06-0
Cas No: 646-06-0
USD $ 1.0-1.0 / Kilogram 1 Kilogram 20 Metric Ton/Month ORCHID CHEMICAL SUPPLIES LTD Contact Supplier
1,3-Dioxolane
Cas No: 646-06-0
USD $ 2.0-3.0 / Kilogram 1 Kilogram 50 Metric Ton/Day EAST CHEMSOURCES LIMITED Contact Supplier
Factory Supply 1,3-dioxolane
Cas No: 646-06-0
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Amadis Chemical offer CAS#646-06-0;CAT#A834826
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No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
1,3-Dioxolane
Cas No: 646-06-0
USD $ 1.0-1.0 / Kilogram 1 Kilogram 1000 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier
Gold quality 1,3-Dioxolane CAS:646-06-0
Cas No: 646-06-0
USD $ 11.0-16.0 / Kilogram 1 Kilogram 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
646-06-0
Cas No: 646-06-0
No Data 1 Kilogram 1000 Kilogram/Week Henan Tianfu Chemical Co., Ltd. Contact Supplier

646-06-0 Usage

Air & Water Reactions

Highly flammable. When exposed to air 1,3-Dioxolane undergoes autooxidation with formation of peroxides. In the distillation process peroxides will concentrate causing violent explosion. Soluble in water.

Chemical Properties

Colourless Liquid

Uses

1,3-Dioxolane is an intermediate for the preparation of Acyclovir (A192400). Also, 1,3-Dioxolane is used in the synthesis of new Vandetanib (V097100) analogs.

Reactivity Profile

Ethers, such as 1,3-Dioxolane, can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.

Definition

ChEBI: A cyclic acetal that is pentane in which the carbon atoms at positions 1 and 3 are replaced by oxygen atoms respectively.

Uses

Intermediate for the preparation of Acyclovir-d4

Purification Methods

Dry it with solid NaOH, KOH or CaSO4, and distil it from sodium or sodium amalgam. Barker et al. [J Chem Soc 802 1959] heated 34mL of dioxalane under reflux with 3g of PbO2 for 2hours, then cooled and filtered. After adding xylene (40mL) and PbO2 (2g) to the filtrate, the mixture is fractionally distilled. Addition of xylene (20mL) and sodium wire to the main fraction (b 70-71o) led to a vigorous reaction, following which the mixture was again fractionally distilled. Xylene and sodium additions are made to the main fraction (b 73-74o) before it is finally distilled. [Beilstein 19/1 V 6.]

Industrial uses

1,3-Dioxolane is used to dissolve a wide spectrum of polymeric materials such as acrylates, alkyds, cellulosics, epoxies, polycarbonates, polyesters, urethanes, and vinyl resins. In many cases, 1,3-dioxolane solvent can replace the chlorinated solvents that were used previously to dissolve many of these polymers. The excellent solvency of 1,3-dioxolane for polymeric compositions makes this cyclic ether a valuable component in paint remover formulations. 1,3-Dioxolane is used to treat polyester fibers for improved dye retention, application of cross-linking agents to cellulosic fibers, and bonding of acrylonitrile polymers. 1,3-Dioxolane is used in metal working and electroplating formulations, as a complexing solvent for organometallic and inorganic salts, and in the preparation of lithium battery electrolyte solutions. 1,3-Dioxolane is a valuable reactant in the polymerization reactions to produce polyacetals. Polymerization reactions of dioxolane with itself or with aldehydes and ethers are catalyzed by a Lewis acid to yield the polyacetal polymers. The methylene group (CH2) bonded to the two oxygen atoms in dioxolane is susceptible to radical abstraction of a hydrogen atom and the resultant dioxolane radical species can be added across various double bond configurations.

Uses

1,3-Dioxolane is used as an intermediate inorganic synthesis.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Mildly toxic by skin contact and inhalation. A shin and severe eye irritant. Mutation data reported. A very dangerous fire hazard when exposed to heat or flame; can react with oxidizers. Used in lithium batteries. Potentially explosive reaction with lithium perchlorate. When heated to decomposition it emits acrid smoke and irritating fumes.

Health Hazard

The acute inhalation and oral toxicity of1,3-dioxolane is low in test animals. Thevapor is irritant to eyes and respiratory tract.Application of the liquid produced severeirritation in rabbits’ eyes and mild action onthe animals’ skin. The information on thetoxicity of this compound in humans is notknown.The inhalation LC50 value of 4-hour exposurein rats is in the range of 20,000 mg/m3,and the oral LD50 is 3000 mg/kg (NIOSH1986).

Health Hazard

Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

General Description

A clear colorless liquid. Flash point 35°F. Slightly denser than water. Vapors heavier than air.
InChI:InChI=1/C3H6O2/c1-2-5-3-4-1/h1-3H2

646-06-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (42897)  1,3-Dioxolane, 99.5%, stab.    646-06-0 250ml 264.0CNY Detail
Alfa Aesar (42897)  1,3-Dioxolane, 99.5%, stab.    646-06-0 1L 687.0CNY Detail
Alfa Aesar (42897)  1,3-Dioxolane, 99.5%, stab.    646-06-0 *4x1L 2433.0CNY Detail
Sigma-Aldrich (271020)  1,3-Dioxolane  anhydrous, contains ~75 ppm BHT as inhibitor, 99.8% 646-06-0 271020-100ML 745.29CNY Detail
Sigma-Aldrich (271020)  1,3-Dioxolane  anhydrous, contains ~75 ppm BHT as inhibitor, 99.8% 646-06-0 271020-1L 1,537.38CNY Detail
Sigma-Aldrich (184497)  1,3-Dioxolane  ReagentPlus®, contains ~75 ppm BHT as inhibitor, 99% 646-06-0 184497-500ML 960.57CNY Detail
Sigma-Aldrich (184497)  1,3-Dioxolane  ReagentPlus®, contains ~75 ppm BHT as inhibitor, 99% 646-06-0 184497-1L 1,226.16CNY Detail

646-06-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,3-dioxolane

1.2 Other means of identification

Product number -
Other names 1,4-dioxolane

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Intermediates,Solvents (for cleaning or degreasing)
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:646-06-0 SDS

646-06-0Synthetic route

formaldehyd
50-00-0

formaldehyd

ethanol
64-17-5

ethanol

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

Conditions
ConditionsYield
With C13H22N4O6S2(2+)*2CF3O3S(1-) In water at 130℃; for 2h; Reagent/catalyst;95.4%
formaldehyd
50-00-0

formaldehyd

ethylene glycol
107-21-1

ethylene glycol

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

Conditions
ConditionsYield
at 60 - 95℃; for 3h; Concentration; Temperature;94.3%
With phosphoric acid
With phosphoric acid; water
ethylene glycol
107-21-1

ethylene glycol

paraformaldehyde

paraformaldehyde

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

Conditions
ConditionsYield
With sulfur dioxide at 105 - 164℃; for 4h;85%
formaldehyd
50-00-0

formaldehyd

(CH2CH2O2)B(O-n-C4H9)
1124-68-1

(CH2CH2O2)B(O-n-C4H9)

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

Conditions
ConditionsYield
With zinc(II) chloride at 130 - 150℃;77%
methanol
67-56-1

methanol

ethylene glycol
107-21-1

ethylene glycol

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

Conditions
ConditionsYield
With iron(III) chloride hexahydrate; sodium nitrite at 50℃; for 24h; UV-irradiation;71%
acetaldehyde
75-07-0

acetaldehyde

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

Conditions
ConditionsYield
In toluene69%
ethylene glycol
107-21-1

ethylene glycol

polyoxymethylene

polyoxymethylene

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

Conditions
ConditionsYield
With bismuth(lll) trifluoromethanesulfonate In 1,4-dioxane at 100℃; for 3h; Sealed tube;66%
With iron(III) chloride
With phosphoric acid at 100℃; im Rohr;
With hydrogenchloride at 100℃;
2-ethoxy-1,3-dioxolane
4544-20-1

2-ethoxy-1,3-dioxolane

A

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

B

ethanol
64-17-5

ethanol

C

2-ethoxymethoxy-ethanol
4468-92-2

2-ethoxymethoxy-ethanol

Conditions
ConditionsYield
With diisobutylaluminium hydride In hexane at 35 - 40℃;A 45%
B n/a
C 45%
formaldehyd
50-00-0

formaldehyd

C9H19BO3
1309123-32-7

C9H19BO3

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

Conditions
ConditionsYield
With zinc(II) chloride at 130 - 150℃;31%
Fe(CO)4(COCH2CH2O)

Fe(CO)4(COCH2CH2O)

A

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

B

iron
7439-89-6

iron

Conditions
ConditionsYield
With H2 In decalin High Pressure; 71.5 atm H2 at room temp., heated to 200°C and stirred for 24 h; pressure realesed, detn. by GC and GC-MS;A 27%
B n/a
formaldehyd
50-00-0

formaldehyd

(CH2CH2O2)B(O-n-C6H13)
92673-07-9

(CH2CH2O2)B(O-n-C6H13)

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

Conditions
ConditionsYield
With zinc(II) chloride at 130 - 150℃;27%
formaldehyd
50-00-0

formaldehyd

2-(3-methyl-butoxy)-[1,3,2]dioxaborolane
118685-83-9

2-(3-methyl-butoxy)-[1,3,2]dioxaborolane

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

Conditions
ConditionsYield
With zinc(II) chloride at 130 - 150℃;24%
oxirane
75-21-8

oxirane

formaldehyd
50-00-0

formaldehyd

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

Conditions
ConditionsYield
With sulfuric acid; water Erhitzen des mit Calciumchlorid versetzten Reaktionsgemisches mit Aethylenglykol unter Zusatz von wss. Salzsaeure;
With sulfuric acid; water Erhitzen des mit Calciumchlorid versetzten Reaktionsgemisches mit Aethylenglykol unter Zusatz von wss. Salzsaeure;
[1,3,5,7,2,6]tetroxadithiocane 2,2,6,6-tetraoxide
20757-83-9

[1,3,5,7,2,6]tetroxadithiocane 2,2,6,6-tetraoxide

ethylene glycol
107-21-1

ethylene glycol

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

Conditions
ConditionsYield
With water
2-ethoxy-1,3-dioxolane
4544-20-1

2-ethoxy-1,3-dioxolane

triethylsilane
617-86-7

triethylsilane

A

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

B

ethoxytriethylsilane
597-67-1

ethoxytriethylsilane

C

1,2-bis (triethylsilyloxy) ethane
13175-68-3

1,2-bis (triethylsilyloxy) ethane

D

(2-Ethoxymethoxy-ethoxy)-triethyl-silane

(2-Ethoxymethoxy-ethoxy)-triethyl-silane

Conditions
ConditionsYield
With nickel at 65℃; for 2h; Yield given. Further byproducts given. Yields of byproduct given;
1,2-di(1,3-dioxolan-2-yloxy)ethane
4544-19-8

1,2-di(1,3-dioxolan-2-yloxy)ethane

A

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

B

2-ethoxy-1,3-dioxolane
4544-20-1

2-ethoxy-1,3-dioxolane

C

[1,3]-dioxolan-2-one
96-49-1

[1,3]-dioxolan-2-one

D

(1,3-dioxolan-2-yloxy)ethanal
85533-22-8

(1,3-dioxolan-2-yloxy)ethanal

E

2-(1,3-dioxolan-2-yloxy)ethyl carbonate
85533-21-7

2-(1,3-dioxolan-2-yloxy)ethyl carbonate

F

formic acid ethyl ester
109-94-4

formic acid ethyl ester

Conditions
ConditionsYield
With di-tert-butyl peroxide at 130℃; for 0.5h; Product distribution;A 0.01 mol
B 0.08 mol
C 0.08 mol
D 0.02 mol
E 0.009 mol
F 0.01 mol
carbon monoxide
201230-82-2

carbon monoxide

A

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

B

propan-1-ol
71-23-8

propan-1-ol

C

ethanol
64-17-5

ethanol

D

ethylene glycol
107-21-1

ethylene glycol

Conditions
ConditionsYield
With 2-hydroxypyridin; hydrogen; acetylacetonatodicarbonylrhodium(l) In various solvent(s) at 230℃; under 1499480 Torr; for 4.5h; Further byproducts given. Title compound not separated from byproducts;A 2 mmol
B 121 mmol
C 191 mmol
D 1000 mmol
ethylene glycol
107-21-1

ethylene glycol

A

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

B

2-methyl-1,3-dioxolane
497-26-7

2-methyl-1,3-dioxolane

C

2-hydroxymethyl-1,3-dioxolane
5694-68-8

2-hydroxymethyl-1,3-dioxolane

D

formic acid
64-18-6

formic acid

E

acetic acid
64-19-7

acetic acid

Conditions
ConditionsYield
With iron(III)-acetylacetonate; oxygen In water at 150℃; for 100h; Product distribution; other acetloacetonates, also in basic solution;
trans-9,10-dihydroxy-9,10-diphenyl-9,10-dihydroanthracene-1,3-dioxolane

trans-9,10-dihydroxy-9,10-diphenyl-9,10-dihydroanthracene-1,3-dioxolane

A

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

B

trans-9,10-dihydroxy-9,10-diphenyl-9,10-dihydroanthracene
36164-98-4

trans-9,10-dihydroxy-9,10-diphenyl-9,10-dihydroanthracene

Conditions
ConditionsYield
at 55℃; under 60 Torr; Thermodynamic data; ΔE(act.), var. temp and pressure;
oxirane
75-21-8

oxirane

1,3,5-Trioxan
110-88-3

1,3,5-Trioxan

A

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

B

1,3,5-trioxepane
5981-06-6

1,3,5-trioxepane

C

1,3,5,7-tetraoxacyclononane

1,3,5,7-tetraoxacyclononane

Conditions
ConditionsYield
With boron trifluoride-butyl ether complex In cyclohexane at 70℃; Title compound not separated from byproducts;
With boron trifluoride-butyl ether complex In cyclohexane at 70℃; Kinetics;
With boron trifluoride-butyl ether complex In cyclohexane at 70℃;A n/a
B n/a
C 33 % Chromat.
oxirane
75-21-8

oxirane

formaldehyd
50-00-0

formaldehyd

sulfuric acid
7664-93-9

sulfuric acid

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

formaldehyd
50-00-0

formaldehyd

sulfuric acid
7664-93-9

sulfuric acid

ethylene glycol
107-21-1

ethylene glycol

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

Conditions
ConditionsYield
at 140℃;
[1,3,5,7,2,6]tetroxadithiocane 2,2,6,6-tetraoxide
20757-83-9

[1,3,5,7,2,6]tetroxadithiocane 2,2,6,6-tetraoxide

water
7732-18-5

water

ethylene glycol
107-21-1

ethylene glycol

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

formaldehyd
50-00-0

formaldehyd

ethylene glycol
107-21-1

ethylene glycol

NaHSO4

NaHSO4

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

Conditions
ConditionsYield
at 140℃;
[1,3]Dioxolane; compound with iodine

[1,3]Dioxolane; compound with iodine

A

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

B

iodine

iodine

Conditions
ConditionsYield
In n-heptane at 20℃; Equilibrium constant; Thermodynamic data; 1/K=0.85 l/mole ΔH=3.0 kcal/mole;
Fe(CO)4(COCH2CH2O)

Fe(CO)4(COCH2CH2O)

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

Conditions
ConditionsYield
With CO; H2 In decalin in presence of 34 atm CO;0%
ethylene glycol
107-21-1

ethylene glycol

A

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

B

ethylene glycol monoformate
628-35-3

ethylene glycol monoformate

Conditions
ConditionsYield
With H5V2Mo10O40*34H2O In sulfolane Kinetics; Mechanism; Temperature; Time; Inert atmosphere;
carbon dioxide
124-38-9

carbon dioxide

ethylene glycol
107-21-1

ethylene glycol

A

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

B

2,2'-methanediyldioxy-bis-ethanol
2565-36-8

2,2'-methanediyldioxy-bis-ethanol

C

ethylene glycol monoformate
628-35-3

ethylene glycol monoformate

Conditions
ConditionsYield
With aluminium(III) triflate; [Ru(1,1,1-tris(diphenylphosphinomethyl)ethane)(trimethylenemethane)]; hydrogen In 1,4-dioxane at 80℃; under 60006 Torr; for 18h; Catalytic behavior; Solvent; Autoclave; Schlenk technique;
carbon dioxide
124-38-9

carbon dioxide

ethylene glycol
107-21-1

ethylene glycol

1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

Conditions
ConditionsYield
With aluminium(III) triflate; [Ru(1,1,1-tris(diphenylphosphinomethyl)ethane)(trimethylenemethane)]; hydrogen In 1,4-dioxane at 80℃; under 60006 Torr; for 18h; Catalytic behavior; Autoclave; Schlenk technique;
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

acetyl chloride
75-36-5

acetyl chloride

1-acetoxy-2-chloromethoxyethane
40510-88-1

1-acetoxy-2-chloromethoxyethane

Conditions
ConditionsYield
With zinc(II) chloride In diethyl ether at 19 - 27℃; for 5.33333h;100%
Stage #1: 1,3-DIOXOLANE With zinc(II) chloride at 20℃; for 0.5h; Inert atmosphere;
Stage #2: acetyl chloride at 20 - 80℃; for 22h; Inert atmosphere;
92%
With zinc(II) chloride83%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

Acetyl bromide
506-96-7

Acetyl bromide

2-acetoxyethoxymethyl bromide
81777-40-4

2-acetoxyethoxymethyl bromide

Conditions
ConditionsYield
at 0 - 20℃;100%
for 2h;93%
at 0℃;88%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

acetaldehyde enolate
64723-93-9

acetaldehyde enolate

Conditions
ConditionsYield
With amide at 24.9℃; OH-;100%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

(S)-α,α-(2-thiophenylethylamino)(2-chlorophenyl)acetonitrile hydrochloride
216249-59-1

(S)-α,α-(2-thiophenylethylamino)(2-chlorophenyl)acetonitrile hydrochloride

(S)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile
444728-17-0

(S)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetonitrile

Conditions
ConditionsYield
at 90℃; for 11h;100%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

homoveratrylamine hydrochloride
635-85-8

homoveratrylamine hydrochloride

6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
1745-07-9

6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Conditions
ConditionsYield
With hydrogenchloride99.8%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

(S,E)-3-(p-tolylsulfinyl)-3-pentene-2-one
207983-95-7

(S,E)-3-(p-tolylsulfinyl)-3-pentene-2-one

5,5-ethylenedioxy-4-methyl-3-(p-tolylsulfinyl)-2-pentanone

5,5-ethylenedioxy-4-methyl-3-(p-tolylsulfinyl)-2-pentanone

Conditions
ConditionsYield
With benzophenone for 0.166667h; Addition; Irradiation;99%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

2-<2-(phenylsulfonyl)ethyl>-1,3-dioxolane
56161-51-4

2-<2-(phenylsulfonyl)ethyl>-1,3-dioxolane

Conditions
ConditionsYield
With (Bu4N)2S2O8 at 25℃; for 3h; Inert atmosphere; regioselective reaction;99%
With 1-(tert-butylperoxy)-1,2-benziodoxol-3(1H)-one at 50℃; for 24h;76%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

ethyl 2-diazo-3-oxobutanoate
2009-97-4

ethyl 2-diazo-3-oxobutanoate

ethyl (4Z)-4-methyl-7,8-dihydro-1,3,6-trioxocine-5-carboxylate

ethyl (4Z)-4-methyl-7,8-dihydro-1,3,6-trioxocine-5-carboxylate

Conditions
ConditionsYield
With copper(II) bis(trifluoromethanesulfonate) In benzene at 80℃; for 4h;99%
With dirhodium tetraacetate at 60℃; for 2h; Inert atmosphere;90%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

boron trichloride
10294-34-5

boron trichloride

ClCH2CO(CH2)2OBCl2

ClCH2CO(CH2)2OBCl2

Conditions
ConditionsYield
-80°C;98.8%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

(S,E)-3-[(2,4,6-triisopropylphenyl)sulfinyl]-3-pentene-2-one
207983-99-1

(S,E)-3-[(2,4,6-triisopropylphenyl)sulfinyl]-3-pentene-2-one

(3R,4R,RS)-5,5-ethylenedioxy-4-methyl-3-[(2,4,6-triisopropylphenyl)sulfinyl]-2-pentanone
220077-33-8

(3R,4R,RS)-5,5-ethylenedioxy-4-methyl-3-[(2,4,6-triisopropylphenyl)sulfinyl]-2-pentanone

Conditions
ConditionsYield
With benzophenone for 0.166667h; Addition; Irradiation;98%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

methyl 4,4-ethylenedioxy-3-methyl-butanoate
77878-20-7

methyl 4,4-ethylenedioxy-3-methyl-butanoate

Conditions
ConditionsYield
With (Bu4N)2S2O8 at 25℃; for 15h; Inert atmosphere; regioselective reaction;98%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

dimethyl cis-but-2-ene-1,4-dioate
624-48-6

dimethyl cis-but-2-ene-1,4-dioate

2-(1,3-dioxolan-2-yl)butanedioic acid 1,4-dimethyl ester
88820-09-1

2-(1,3-dioxolan-2-yl)butanedioic acid 1,4-dimethyl ester

Conditions
ConditionsYield
With (Bu4N)2S2O8 at 25℃; for 1.5h; Inert atmosphere; regioselective reaction;98%
With 1-hydroxy-pyrrolidine-2,5-dione; dimethylglyoxal at 20℃; for 3h; Irradiation; Sealed tube; Inert atmosphere;96%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

1,4-dimethyl but-2-enedioate
23055-10-9

1,4-dimethyl but-2-enedioate

2-(1,3-dioxolan-2-yl)butanedioic acid 1,4-dimethyl ester
88820-09-1

2-(1,3-dioxolan-2-yl)butanedioic acid 1,4-dimethyl ester

Conditions
ConditionsYield
With (Bu4N)2S2O8 at 25℃; for 1.5h; Inert atmosphere; regioselective reaction;98%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

triethylsilane
617-86-7

triethylsilane

1-methoxy-2-(triethylsiloxy)-ethane
73993-16-5

1-methoxy-2-(triethylsiloxy)-ethane

Conditions
ConditionsYield
nickel at 80 - 100℃; for 1h;97%
zinc(II) chloride at 140℃; for 12h;62%
With zinc(II) chloride at 140℃; Product distribution; Rate constant;
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

dibenzo-18-crown-6
14187-32-7

dibenzo-18-crown-6

sodium thiocyanide
540-72-7

sodium thiocyanide

C20H24O6*C3H6O2*CNS(1-)*Na(1+)

C20H24O6*C3H6O2*CNS(1-)*Na(1+)

Conditions
ConditionsYield
for 1h; Ambient temperature;97%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

cyclopent-2-enone
930-30-3

cyclopent-2-enone

3-[1,3]Dioxolan-2-yl-cyclopentanone

3-[1,3]Dioxolan-2-yl-cyclopentanone

Conditions
ConditionsYield
With (Bu4N)2S2O8 at 20 - 25℃;97%
With (Bu4N)2S2O8 at 25℃; for 18h; Inert atmosphere; regioselective reaction;97%
With (Bu4N)2S2O8 at 25℃; Yield given;
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

(S)-2-[(2,4,6-triisopropylphenyl)sulfinyl]-2-cyclopentenone
151951-76-7

(S)-2-[(2,4,6-triisopropylphenyl)sulfinyl]-2-cyclopentenone

(2R,3R,RS)-3-(1,3-dioxolan-2-yl)-2-[(2,4,6-triisopropylphenyl)sulfinyl]-1-cyclopentanone
220077-00-9

(2R,3R,RS)-3-(1,3-dioxolan-2-yl)-2-[(2,4,6-triisopropylphenyl)sulfinyl]-1-cyclopentanone

Conditions
ConditionsYield
With benzophenone for 0.166667h; Addition; Irradiation;97%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

(E)-N-(4-bromophenyl)-1-(2,4-dichlorophenyl)methanimine

(E)-N-(4-bromophenyl)-1-(2,4-dichlorophenyl)methanimine

4-bromo-N-((2,4-dichlorophenyl)(1,3-dioxolan-2-yl)methyl)aniline

4-bromo-N-((2,4-dichlorophenyl)(1,3-dioxolan-2-yl)methyl)aniline

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile); 2,3,3,4,4,5-hexamethyl-2-hexanethiol at 80℃; for 10h; Sealed tube; Molecular sieve;97%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

dimethyl 2-benzylidenepropanedioate
6626-84-2

dimethyl 2-benzylidenepropanedioate

dimethyl 2-((1,3-dioxolan-2-yl)(phenyl)methyl)malonate

dimethyl 2-((1,3-dioxolan-2-yl)(phenyl)methyl)malonate

Conditions
ConditionsYield
With fac-tris[2-phenylpyridinato-C2,N]iridium(III); (Bu4N)2S2O8 at 30℃; for 24h; Reagent/catalyst; Inert atmosphere; Sealed tube; Irradiation;97%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

4'-methylpropiophenone
5337-93-9

4'-methylpropiophenone

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

Tolperisone hydrochloride

Tolperisone hydrochloride

Conditions
ConditionsYield
With hydrogenchloride at 90℃; for 8h;96%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

(5S)-5-(tert-butyldiphenylsiloxymethyl)-2(5H)-furanone
99315-76-1

(5S)-5-(tert-butyldiphenylsiloxymethyl)-2(5H)-furanone

(4S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-[1,3]dioxolan-2-yl-dihydro-furan-2-one

(4S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-[1,3]dioxolan-2-yl-dihydro-furan-2-one

Conditions
ConditionsYield
With (Bu4N)2S2O896%
With (Bu4N)2S2O8 at 30℃; for 0.25h;96%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

2-[(S)-(4-methylphenyl)sulfinyl]cyclopent-2-en-1-one
79681-26-8

2-[(S)-(4-methylphenyl)sulfinyl]cyclopent-2-en-1-one

(2R*,3R*,RS)-3-(1,3-dioxolan-2-yl)-2-(p-tolylsulfinyl)-1-cyclopentanone

(2R*,3R*,RS)-3-(1,3-dioxolan-2-yl)-2-(p-tolylsulfinyl)-1-cyclopentanone

Conditions
ConditionsYield
With benzophenone for 0.166667h; Addition; Irradiation;96%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

dichloro-(2-chloromethoxy-ethoxy)-borane
856611-83-1

dichloro-(2-chloromethoxy-ethoxy)-borane

bis(chloromethoxyethoxy)chloroborane
89582-76-3

bis(chloromethoxyethoxy)chloroborane

Conditions
ConditionsYield
96%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

6-chloro-1-[(2'-hydroxyethoxy)methyl]-N-[(phenyl)methyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
1185869-41-3

6-chloro-1-[(2'-hydroxyethoxy)methyl]-N-[(phenyl)methyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

Conditions
ConditionsYield
Stage #1: C17H13ClN2O2 With chloro-trimethyl-silane; N,O-Bis(trimethylsilyl)trifluoroacetamide In acetonitrile for 4h; Inert atmosphere; Reflux;
Stage #2: 1,3-DIOXOLANE With chloro-trimethyl-silane; potassium iodide In acetonitrile at 20℃; for 24h;
Stage #3: With water; sodium hydrogencarbonate In acetonitrile
96%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

glyoxylic acid ethyl ester
924-44-7

glyoxylic acid ethyl ester

aniline
62-53-3

aniline

ethyl 2-(1,3-dioxolan-2-yl)-2-(phenylamino)acetate

ethyl 2-(1,3-dioxolan-2-yl)-2-(phenylamino)acetate

Conditions
ConditionsYield
Stage #1: 1,3-DIOXOLANE; glyoxylic acid ethyl ester; aniline In toluene at 20℃; for 1h; Sealed tube; Molecular sieve;
Stage #2: With 2,2'-azobis(isobutyronitrile); 2,3,3,4,4,5-hexamethyl-2-hexanethiol In toluene at 80℃; for 12h; Sealed tube; Molecular sieve; regioselective reaction;
96%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

glyoxylic acid ethyl ester
924-44-7

glyoxylic acid ethyl ester

4-methoxy-aniline
104-94-9

4-methoxy-aniline

ethyl 2-(1,3-dioxolan-2-yl)-2-((4-methoxyphenyl)amino)acetate

ethyl 2-(1,3-dioxolan-2-yl)-2-((4-methoxyphenyl)amino)acetate

Conditions
ConditionsYield
Stage #1: 1,3-DIOXOLANE; glyoxylic acid ethyl ester; 4-methoxy-aniline In toluene at 20℃; for 1h; Sealed tube; Molecular sieve;
Stage #2: With 2,2'-azobis(isobutyronitrile); 2,3,3,4,4,5-hexamethyl-2-hexanethiol In toluene at 80℃; for 12h; Sealed tube; Molecular sieve;
96%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

2,2,2-trifluoro-N-hexylethan-1-imine

2,2,2-trifluoro-N-hexylethan-1-imine

C11H20F3NO2

C11H20F3NO2

Conditions
ConditionsYield
With 1-hydroxy-pyrrolidine-2,5-dione; dimethylglyoxal at 20℃; Molecular sieve; Irradiation; Inert atmosphere;96%
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

formic acid-(2-bromo-ethyl ester)
6065-67-4

formic acid-(2-bromo-ethyl ester)

Conditions
ConditionsYield
With Bromoform; (RCO2)2 at 20 - 60℃; for 3h; Irradiation;95%
With 1,4-Dioxane Dibromide In tetrachloromethane at 29.9℃; Rate constant; Thermodynamic data; Mechanism; ΔH(excit.), ΔS(excit.), ΔG(excit.), lg A; further temp., kinetics;
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

1-(4-ethylphenyl)-1-propanone
27465-51-6

1-(4-ethylphenyl)-1-propanone

piperidine hydrochloride
6091-44-7

piperidine hydrochloride

eperisone hydrochloride
56839-43-1

eperisone hydrochloride

Conditions
ConditionsYield
With hydrogenchloride at 90℃; for 6.5h;95%

646-06-0Upstream product

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