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Gold quality 1,3-Dioxolane CAS:646-06-0
Cas No: 646-06-0
USD $ 190.0-200.0 / Kilogram 1 Kilogram 1 Metric Ton/Week Chemical Co.Ltd Contact Supplier
1,3-Dioxolane Manufacturer/High quality/Best price/In stock
Cas No: 646-06-0
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier
Gold quality 1,3-Dioxolane CAS:646-06-0
Cas No: 646-06-0
USD $ 11.0-16.0 / Kilogram 1 Kilogram 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
1,3-Dioxolane CAS#646-06-0
Cas No: 646-06-0
USD $ 1.0-1.0 / Kilogram 1 Kilogram 20 Metric Ton/Month ORCHID CHEMICAL SUPPLIES LTD Contact Supplier
High quality 1,3-Dioxolane supplier in China
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No Data No Data No Data Simagchem Corporation Contact Supplier
1,3-Dioxolane
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No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
646-06-0 C3H6O2 1,3-Dioxolane
Cas No: 646-06-0
No Data 10 Gram 1 Kilogram/Day HENAN SUNLAKE ENTERPRISE CORPORATION Contact Supplier
646-06-0
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No Data 1 Kilogram 1000 Kilogram/Week Henan Tianfu Chemical Co., Ltd. Contact Supplier
1,3-Dioxolane
Cas No: 646-06-0
USD $ 12.0-12.0 / Metric Ton 1 Metric Ton 100 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
sell high purity of 1,3-Dioxolane
Cas No: 646-06-0
No Data 1 Kilogram 100 Metric Ton/Month Crovell Biotech (Hebei) Co., Ltd. Contact Supplier

646-06-0 Usage

Reactivity Profile

Ethers, such as 1,3-Dioxolane, can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.

Purification Methods

Dry it with solid NaOH, KOH or CaSO4, and distil it from sodium or sodium amalgam. Barker et al. [J Chem Soc 802 1959] heated 34mL of dioxalane under reflux with 3g of PbO2 for 2hours, then cooled and filtered. After adding xylene (40mL) and PbO2 (2g) to the filtrate, the mixture is fractionally distilled. Addition of xylene (20mL) and sodium wire to the main fraction (b 70-71o) led to a vigorous reaction, following which the mixture was again fractionally distilled. Xylene and sodium additions are made to the main fraction (b 73-74o) before it is finally distilled. [Beilstein 19/1 V 6.]

Uses

Intermediate for the preparation of Acyclovir-d4

Air & Water Reactions

Highly flammable. When exposed to air 1,3-Dioxolane undergoes autooxidation with formation of peroxides. In the distillation process peroxides will concentrate causing violent explosion. Soluble in water.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Chemical Properties

Colourless Liquid

General Description

A clear colorless liquid. Flash point 35°F. Slightly denser than water. Vapors heavier than air.

Definition

ChEBI: A cyclic acetal that is pentane in which the carbon atoms at positions 1 and 3 are replaced by oxygen atoms respectively.

Uses

1,3-Dioxolane is an intermediate for the preparation of Acyclovir (A192400). Also, 1,3-Dioxolane is used in the synthesis of new Vandetanib (V097100) analogs.

Health Hazard

Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control may cause pollution.
InChI:InChI=1/C3H6O2/c1-2-5-3-4-1/h1-3H2

646-06-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (184497)  1,3-Dioxolane  ReagentPlus®, contains ~75 ppm BHT as inhibitor, 99% 646-06-0 184497-1L 1,226.16CNY Detail
Sigma-Aldrich (184497)  1,3-Dioxolane  ReagentPlus®, contains ~75 ppm BHT as inhibitor, 99% 646-06-0 184497-500ML 960.57CNY Detail
Sigma-Aldrich (271020)  1,3-Dioxolane  anhydrous, contains ~75 ppm BHT as inhibitor, 99.8% 646-06-0 271020-1L 1,537.38CNY Detail
Sigma-Aldrich (271020)  1,3-Dioxolane  anhydrous, contains ~75 ppm BHT as inhibitor, 99.8% 646-06-0 271020-100ML 745.29CNY Detail
Alfa Aesar (42897)  1,3-Dioxolane, 99.5%, stab.    646-06-0 *4x1L 2433.0CNY Detail
Alfa Aesar (42897)  1,3-Dioxolane, 99.5%, stab.    646-06-0 1L 687.0CNY Detail
Alfa Aesar (42897)  1,3-Dioxolane, 99.5%, stab.    646-06-0 250ml 264.0CNY Detail

646-06-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,3-dioxolane

1.2 Other means of identification

Product number -
Other names 1,4-dioxolane

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Intermediates,Solvents (for cleaning or degreasing)
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:646-06-0 SDS

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