N-(5-{[4-(4-{2-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}-ethyl)amino]ethyl}anilino)piperidin-1-yl]sulfonyl}-4-methyl-1,3-thiazol-2-yl)acetamide

Base Information

• Chemical Name: N-(5-{[4-(4-{2-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}-ethyl)amino]ethyl}anilino)piperidin-1-yl]sulfonyl}-4-methyl-1,3-thiazol-2-yl)acetamide
• CAS No.: 392642-64-7
• Molecular Formula: C₂₈H₃₈N₆O₇S₃
• Molecular Weight: 666.844
• Mol file: 392642-64-7.mol

Synonyms:N-(5-{[4-(4-{2-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}-ethyl)amino]ethyl}anilino)piperidin-1-yl]sulfonyl}-4-methyl-1,3-thiazol-2-yl)acetamide

Chemical Property of N-(5-{[4-(4-{2-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}-ethyl)amino]ethyl}anilino)piperidin-1-yl]sulfonyl}-4-methyl-1,3-thiazol-2-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-{[4-(4-{2-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}-ethyl)amino]ethyl}anilino)piperidin-1-yl]sulfonyl}-4-methyl-1,3-thiazol-2-yl)acetamide

There total 4 articles about N-(5-{[4-(4-{2-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}-ethyl)amino]ethyl}anilino)piperidin-1-yl]sulfonyl}-4-methyl-1,3-thiazol-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methyltrichlorosilane (75-79-6) + N-[5-({4-[4-(2,2-dimethoxyethyl)anilino]-1-piperidinyl}sulfonyl)-4-methyl-1,3-thiazol-2-yl]acetamide + chloroform methanol (7285-11-2) + N-[5-((1R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide (340756-75-4) → N-(5-{[4-(4-{2-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}-ethyl)amino]ethyl}anilino)piperidin-1-yl]sulfonyl}-4-methyl-1,3-thiazol-2-yl)acetamide (392642-64-7)

Guidance literature:

With ammonium hydroxide; sodium iodide; sodium cyanoborohydride; acetic acid; In methanol; dichloromethane; acetonitrile;

Reference yield:

1-(2,2-Dimethoxyethyl)-4-nitro-benzene (18436-62-9) → N-(5-{[4-(4-{2-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}-ethyl)amino]ethyl}anilino)piperidin-1-yl]sulfonyl}-4-methyl-1,3-thiazol-2-yl)acetamide (392642-64-7)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium formate / palladium / ethanol

2: sodium tris(acetoxy)borohydride; acetic acid; sodium sulfate / 1,1-dichloroethane

3: ammonium hydroxide; sodium iodide; sodium cyanoborohydride; acetic acid / methanol; dichloromethane; acetonitrile

With ammonium hydroxide; sodium iodide; ammonium formate; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; acetic acid; sodium sulfate; palladium; In methanol; 1,1-dichloroethane; ethanol; dichloromethane; acetonitrile;

Reference yield:

N-[5-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylsulfonyl)-4-methyl-1,3-thiazol-2-yl]acetamide → N-(5-{[4-(4-{2-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}-ethyl)amino]ethyl}anilino)piperidin-1-yl]sulfonyl}-4-methyl-1,3-thiazol-2-yl)acetamide (392642-64-7)

Guidance literature:

Multi-step reaction with 3 steps

1: formic acid; water

2: sodium tris(acetoxy)borohydride; acetic acid; sodium sulfate / 1,1-dichloroethane

3: ammonium hydroxide; sodium iodide; sodium cyanoborohydride; acetic acid / methanol; dichloromethane; acetonitrile

With ammonium hydroxide; sodium iodide; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; acetic acid; sodium sulfate; In methanol; formic acid; 1,1-dichloroethane; dichloromethane; water; acetonitrile;

upstream raw materials:

Methyltrichlorosilane

chloroform methanol

N-[5-((1R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide

4-(2,2-dimethoxyethyl)aniline