18436-62-9

Upstream product

• 67-56-1 methanol 
• 18462-35-6 (E)-1-[2-bromovinyl]-4-nitrobenzene 
• 1460-05-5 p-nitrophenylacetaldehyde 
• 149-73-5 trimethyl orthoformate 
• 18462-34-5 (Z)-1-(2-bromovinyl)-4-nitrobenzene 
• 75867-38-8 4-nitro-1-(trimethylsilylethynyl)benzene 

Downstream Products

• 1459-12-7 (p-nitrophenyl)acetaldehyde oxime 
• 392630-73-8 4-(2,2-dimethoxyethyl)aniline 
• 392630-81-8 N-[4-(2,2-dimethoxyethyl)phenyl]-4-piperidinamine 
• 392630-77-2 1-Benzyl-N-[4-(2,2-dimethoxyethyl)phenyl]-4-piperidinamine 
• 392642-64-7 N-(5-{[4-(4-{2-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}-ethyl)amino]ethyl}anilino)piperidin-1-yl]sulfonyl}-4-methyl-1,3-thiazol-2-yl)acetamide 

Relevant academic research and scientific papers

Microwave-assisted in situ deprotection and ω-methoxylation of TMS-protected aryl alkynes

Using microwave technology, rapid ω-methoxylation of aryl alkynes is possible.

4-Aminopiperidine ureas as potent selective agonists of the human β3-Adrenergic receptor

The preparation and structure-activity relationships (SARs) of potent agonists of the human β3-adrenergic receptor (AR) derived from a 4-aminopiperidine scaffold are described. Examples combine human β3-AR potency with selectivity over human β1-AR and/or human β2-AR agonism. Compound 29s was identified as a potent (EC50 = 1 nM) and selective (greater than 400-fold over β1- with no β2-AR agonism) full β3-AR agonist with in vivo activity in a transgenic mouse model of thermogenesis.