((2R,4R)-1-(4-(benzyloxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol

Base Information

Chemical Name:((2R,4R)-1-(4-(benzyloxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol
CAS No.:1610033-06-1
Molecular Formula:C₁₉H₂₀F₃NO₂
Molecular Weight:351.369
Hs Code.:

Synonyms:((2R,4R)-1-(4-(benzyloxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol

Suppliers and Price of ((2R,4R)-1-(4-(benzyloxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ((2R,4R)-1-(4-(benzyloxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ((2R,4R)-1-(4-(benzyloxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol

There total 11 articles about ((2R,4R)-1-(4-(benzyloxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: ((2R,4R)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol (1R)-(-)-10-camphorsulfonic acid salt

: 19578-68-8
4-(4-benzyloxyphenyl) iodide

: 1610033-06-1
((2R,4R)-1-(4-(benzyloxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol

Guidance literature:: With copper(l) iodide; sodium hydroxide; In butan-1-ol; for 90h; Inert atmosphere;

Reference yield: 65.0%

: 19578-68-8
4-(4-benzyloxyphenyl) iodide

: C₆H₁₀F₃NO*C₁₀H₁₆O₄S

: 1610033-06-1
((2R,4R)-1-(4-(benzyloxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol

Guidance literature:: With copper(l) iodide; sodium hydroxide; In butan-1-ol; at 90 ℃; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b00982

Reference yield:

: ((2R,4R)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol hydrochloride

: 1610033-06-1
((2R,4R)-1-(4-(benzyloxy)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 20 °C / Inert atmosphere

2: sodium hydroxide; copper(l) iodide / butan-1-ol / 90 °C / Inert atmosphere

With copper(l) iodide; sodium hydroxide; In ethanol; butan-1-ol;
DOI:10.1021/acs.jmedchem.7b00982