(R)-1-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-methylpropan-1-amine hydrochloride

Base Information

Chemical Name:(R)-1-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-methylpropan-1-amine hydrochloride
CAS No.:1198223-11-8
Molecular Formula:C₁₄H₂₀FNO*ClH
Molecular Weight:273.778
Hs Code.:

Synonyms:(R)-1-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-methylpropan-1-amine hydrochloride

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Chemical Property of (R)-1-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-methylpropan-1-amine hydrochloride

Chemical Property:

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Technology Process of (R)-1-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-methylpropan-1-amine hydrochloride

There total 10 articles about (R)-1-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-methylpropan-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-N-((R)-1-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-methylpropyl)-2-methylpropane-2-sulfinamide

: 1198223-11-8
(R)-1-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-methylpropan-1-amine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 0.5h;

Reference yield:

: 51446-31-2
4-fluoro-3-hydroxybenzoic acid

: 1198223-11-8
(R)-1-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-methylpropan-1-amine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 6 h / 90 °C

1.2: 2 h / 0 °C

2.1: manganese(IV) oxide / dichloromethane / 6 h / 45 °C

3.1: titanium(IV) isopropylate / toluene / 6 h / 75 °C

4.1: tetrahydrofuran / 0.75 h / -78 °C

4.2: -78 °C

5.1: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; manganese(IV) oxide; potassium carbonate; potassium iodide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 351317-28-7
ethyl 3-hydroxy-4-fluorobenzoate

: 1198223-11-8
(R)-1-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-methylpropan-1-amine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 3.5 h / 90 °C

2.1: lithium borohydride / tetrahydrofuran / 3.5 h / 80 °C

2.2: 0 °C

3.1: manganese(IV) oxide / dichloromethane / 6 h / 45 °C

4.1: titanium(IV) isopropylate / toluene / 6 h / 75 °C

5.1: tetrahydrofuran / 0.75 h / -78 °C

5.2: -78 °C

6.1: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; manganese(IV) oxide; lithium borohydride; potassium carbonate; potassium iodide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;