(E)-3-(2-methyl-4-nitrobenzylidene)-4-tosyl-3,4-dihydro-2H-1,4-benzoxazine

Base Information

Chemical Name:(E)-3-(2-methyl-4-nitrobenzylidene)-4-tosyl-3,4-dihydro-2H-1,4-benzoxazine
CAS No.:1232133-34-4
Molecular Formula:C₂₃H₂₀N₂O₅S
Molecular Weight:436.488
Hs Code.:

Synonyms:(E)-3-(2-methyl-4-nitrobenzylidene)-4-tosyl-3,4-dihydro-2H-1,4-benzoxazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-(2-methyl-4-nitrobenzylidene)-4-tosyl-3,4-dihydro-2H-1,4-benzoxazine

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Technology Process of (E)-3-(2-methyl-4-nitrobenzylidene)-4-tosyl-3,4-dihydro-2H-1,4-benzoxazine

There total 5 articles about (E)-3-(2-methyl-4-nitrobenzylidene)-4-tosyl-3,4-dihydro-2H-1,4-benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1232133-29-7
4-methyl-N-(2-(prop-2-ynyloxy)phenyl)benzenesulfonamide

: 5326-38-5
2-iodo-5-nitrotoluene

: 1232133-34-4
(E)-3-(2-methyl-4-nitrobenzylidene)-4-tosyl-3,4-dihydro-2H-1,4-benzoxazine

Guidance literature:: With tetrabutylammomium bromide; palladium diacetate; potassium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; at 35 - 40 ℃; for 2.5h; stereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tetlet.2010.03.081

Reference yield:

: 52536-39-7
2-(prop-2-ynyloxy)benzenediazonium tetrafluoroborate

: 1232133-34-4
(E)-3-(2-methyl-4-nitrobenzylidene)-4-tosyl-3,4-dihydro-2H-1,4-benzoxazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 0.17 h / 0 °C

1.2: 3 h / 20 °C / Inert atmosphere

2.1: palladium diacetate; triphenylphosphine; potassium carbonate; tetrabutylammomium bromide / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 2.5 h / 20 °C / Inert atmosphere

With pyridine; tetrabutylammomium bromide; palladium diacetate; potassium carbonate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2014.06.036

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1232133-34-4
(E)-3-(2-methyl-4-nitrobenzylidene)-4-tosyl-3,4-dihydro-2H-1,4-benzoxazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 0.17 h / 0 °C

1.2: 3 h / 20 °C / Inert atmosphere

2.1: palladium diacetate; triphenylphosphine; potassium carbonate; tetrabutylammomium bromide / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 2.5 h / 20 °C / Inert atmosphere

With pyridine; tetrabutylammomium bromide; palladium diacetate; potassium carbonate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2014.06.036