Technology Process of (3aα,6aα)-1,2,3,3a,6,6a-Hexahydro-2,2,4-trimethyl-3a-(phenylmethoxy)pentalene
There total 7 articles about (3aα,6aα)-1,2,3,3a,6,6a-Hexahydro-2,2,4-trimethyl-3a-(phenylmethoxy)pentalene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydride;
In
tetrahydrofuran;
at 25 ℃;
for 2h;
DOI:10.1021/jo00006a020
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1) NaH / 1) toluene, reflux, 2 h, 2) toluene, reflux, 16 h
2: 1) O3, 2) Zn powder, 50 percent aq. AcOH / 1) -78 deg C, CH2Cl2, 2) 25 deg C, 45 min
3: NaH / toluene / 18 h / Heating
4: LiI*3H2O / dimethylformamide / 18 h / Heating
5: 69 percent / aq. H2O2, 4.0 N aq. NaOH / methanol / 6 h / 0 °C
6: 41 percent / N2H4*H2O / methanol / 120 h / 0 °C
7: 99 percent / KH / tetrahydrofuran / 2 h / 25 °C
With
sodium hydroxide; dihydrogen peroxide; potassium hydride; sodium hydride; ozone; hydrazine hydrate; acetic acid; lithium iodide; zinc;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00006a020
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 69 percent / aq. H2O2, 4.0 N aq. NaOH / methanol / 6 h / 0 °C
2: 41 percent / N2H4*H2O / methanol / 120 h / 0 °C
3: 99 percent / KH / tetrahydrofuran / 2 h / 25 °C
With
sodium hydroxide; dihydrogen peroxide; potassium hydride; hydrazine hydrate;
In
tetrahydrofuran; methanol;
DOI:10.1021/jo00006a020
