Technology Process of (R,R)-(6'-iodo-N-carbobenzyloxytryptophyl)-3',5'-dichloro-4'-hydroxyphenylglycine tert-butyl ester
There total 11 articles about (R,R)-(6'-iodo-N-carbobenzyloxytryptophyl)-3',5'-dichloro-4'-hydroxyphenylglycine tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pentafluorophenyl diphenyl-phosphinate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
DOI:10.1248/cpb.53.1277
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 96 percent / pyridine / 1.4 h / 20 °C
2: 100 percent / H2 / Pd/C / methanol / 1.4 h / 20 °C
3: 62 percent / aq. NaNO2; AcOH; KI / 24 h / 0 °C
4: 71 percent / aq. NaOH / methanol / 4.5 h / 75 °C
5: 98 percent / salcomine; O2 / methanol / 3.5 h / 20 °C
6: 89 percent / AcOH / 2 h / 75 °C
7: 48.3 percent / D-aminocyclase; aq. phosphate buffer; CoCl2 / 47 h / 37 °C / pH 7.4
8: 100 percent / aq. Na2CO3 / diethyl ether / 3 h / 0 °C
9: 64 percent / i-Pr2NEt; FDPP / tetrahydrofuran / 24 h / 20 °C
With
pyridine; sodium hydroxide; phosphate buffer; D-aminocyclase; salcomine; pentafluorophenyl diphenyl-phosphinate; hydrogen; oxygen; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether;
DOI:10.1248/cpb.53.1277
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 100 percent / H2 / Pd/C / methanol / 1.4 h / 20 °C
2: 62 percent / aq. NaNO2; AcOH; KI / 24 h / 0 °C
3: 71 percent / aq. NaOH / methanol / 4.5 h / 75 °C
4: 98 percent / salcomine; O2 / methanol / 3.5 h / 20 °C
5: 89 percent / AcOH / 2 h / 75 °C
6: 48.3 percent / D-aminocyclase; aq. phosphate buffer; CoCl2 / 47 h / 37 °C / pH 7.4
7: 100 percent / aq. Na2CO3 / diethyl ether / 3 h / 0 °C
8: 64 percent / i-Pr2NEt; FDPP / tetrahydrofuran / 24 h / 20 °C
With
sodium hydroxide; phosphate buffer; D-aminocyclase; salcomine; pentafluorophenyl diphenyl-phosphinate; hydrogen; oxygen; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether;
DOI:10.1248/cpb.53.1277
