Technology Process of 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexanone
There total 7 articles about 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-(6-phenylpyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclohexanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 7 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / 0 °C
1.2: 0 - 20 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C
2.2: 1 h / -78 - 0 °C
3.1: acetic acid / 100 °C / sealed tube
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 45 °C
5.1: 2,6-dimethylpyridine; sodium periodate / osmium(VIII) oxide / 1,4-dioxane; tert-butyl alcohol / 20 °C
6.1: N-iodo-succinimide / acetonitrile / 0.5 h / 20 °C
7.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; water / 16 h / 90 °C
With
2,6-dimethylpyridine; potassium phosphate; sodium periodate; N-iodo-succinimide; n-butyllithium; acetic acid; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide;
osmium(VIII) oxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C
1.2: 1 h / -78 - 0 °C
2.1: acetic acid / 100 °C / sealed tube
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 45 °C
4.1: 2,6-dimethylpyridine; sodium periodate / osmium(VIII) oxide / 1,4-dioxane; tert-butyl alcohol / 20 °C
5.1: N-iodo-succinimide / acetonitrile / 0.5 h / 20 °C
6.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; water / 16 h / 90 °C
With
2,6-dimethylpyridine; potassium phosphate; sodium periodate; N-iodo-succinimide; n-butyllithium; acetic acid; N-ethyl-N,N-diisopropylamine;
osmium(VIII) oxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N-iodo-succinimide / acetonitrile / 0.5 h / 20 °C
2: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; water / 16 h / 90 °C
With
potassium phosphate; N-iodo-succinimide;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
1,4-dioxane; water; acetonitrile;
