3,7-Dihydro-2-methylthio-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)-4H-pyrrolo<2,3-d>pyrimidin-4-on

Base Information

Chemical Name:3,7-Dihydro-2-methylthio-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)-4H-pyrrolo<2,3-d>pyrimidin-4-on
CAS No.:79816-02-7
Molecular Formula:C₃₃H₃₃N₃O₅S
Molecular Weight:583.708
Hs Code.:

Synonyms:3,7-Dihydro-2-methylthio-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)-4H-pyrrolo<2,3-d>pyrimidin-4-on

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Chemical Property of 3,7-Dihydro-2-methylthio-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)-4H-pyrrolo<2,3-d>pyrimidin-4-on

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Technology Process of 3,7-Dihydro-2-methylthio-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)-4H-pyrrolo<2,3-d>pyrimidin-4-on

There total 1 articles about 3,7-Dihydro-2-methylthio-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)-4H-pyrrolo<2,3-d>pyrimidin-4-on which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 72564-98-8
4-Methoxy-2-methylthio-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)-7H-pyrrolo<2,3-d>pyrimidin

: 79816-02-7
3,7-Dihydro-2-methylthio-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)-4H-pyrrolo<2,3-d>pyrimidin-4-on

Guidance literature:: With hydrogenchloride; 2,2'-Dimethyl-5,5'-di-tert-butyl-4,4'-dihydroxy-diphenyl-sulfid, Lanotox; In 1,4-dioxane; for 16h; Heating;
DOI:10.1021/jo00341a009

Reference yield:

: 79816-02-7
3,7-Dihydro-2-methylthio-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)-4H-pyrrolo<2,3-d>pyrimidin-4-on

: 79816-05-0
4-Amino-3,7-dihydro-3-methoxymethyl-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)-4H-pyrrolo<2,3-d>pyrimidin-4-on

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) dimethoxyethane, 0 deg C, 10 min, 2.) RT, 50 min

2: 1) NaH / 1.) 100 deg C, 2.) 100 deg C, 40 min

3: 94 percent / conc. ammonia / methanol / 12 h / Ambient temperature

With ammonium hydroxide; sodium hydride; In methanol;
DOI:10.1021/jo00341a009

Reference yield:

: 79816-02-7
3,7-Dihydro-2-methylthio-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)-4H-pyrrolo<2,3-d>pyrimidin-4-on

: 79816-04-9
2-Acetamido-3,7-dihydro-3-methoxymethyl-7-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)-4H-pyrrolo<2,3-d>pyrimidin-4-on

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) dimethoxyethane, 0 deg C, 10 min, 2.) RT, 50 min

2: 1) NaH / 1.) 100 deg C, 2.) 100 deg C, 40 min

With sodium hydride;
DOI:10.1021/jo00341a009