6-nitro-7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (2-(4-fluorphenyl)ethyl)amide

Base Information

Chemical Name:6-nitro-7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (2-(4-fluorphenyl)ethyl)amide
CAS No.:1338350-76-7
Molecular Formula:C₂₃H₂₄FN₃O₆
Molecular Weight:457.458
Hs Code.:

Synonyms:6-nitro-7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (2-(4-fluorphenyl)ethyl)amide

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Chemical Property of 6-nitro-7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (2-(4-fluorphenyl)ethyl)amide

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Technology Process of 6-nitro-7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (2-(4-fluorphenyl)ethyl)amide

There total 8 articles about 6-nitro-7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (2-(4-fluorphenyl)ethyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1338350-75-6
7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid 2-(4-amino-phenyl)ethylamide

: 283178-65-4
7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (2-(4-fluorphenyl)ethyl)amide

: 1338350-76-7
6-nitro-7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (2-(4-fluorphenyl)ethyl)amide

Guidance literature:: With pyridine hydrogenfluoride; sodium nitrite; at 20 - 85 ℃; for 2h;
DOI:10.1016/j.bmc.2011.07.062

Reference yield:

: 621-59-0
isovanillin

: 283178-65-4
7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (2-(4-fluorphenyl)ethyl)amide

: 1338350-76-7
6-nitro-7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (2-(4-fluorphenyl)ethyl)amide

Guidance literature:: Multi-step reaction with 8 steps

1: nitronium tetrafluoborate / dichloromethane / 24 h / -20 °C / Inert atmosphere

2: caesium carbonate; sodium iodide / N,N-dimethyl-formamide / 25 h / 20 - 80 °C / Inert atmosphere

3: hydrogenchloride; iron; acetic acid / water; ethyl acetate / 0.25 h / Reflux

4: piperidine; acetic acid / ethanol / 16 h / Reflux; Inert atmosphere

5: hydrogenchloride; water / ethanol / 60 °C

6: thionyl chloride / toluene / 3 h / Reflux; Inert atmosphere

7: triethylamine / dichloromethane / 16 h / 0 - 20 °C

8: pyridine hydrogenfluoride; sodium nitrite / 2 h / 20 - 85 °C

With piperidine; hydrogenchloride; thionyl chloride; nitronium tetrafluoborate; water; iron; caesium carbonate; pyridine hydrogenfluoride; acetic acid; triethylamine; sodium iodide; sodium nitrite; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.07.062

Reference yield:

: 1192134-02-3
C₁₂H₁₇NO₃

: 283178-65-4
7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (2-(4-fluorphenyl)ethyl)amide

: 1338350-76-7
6-nitro-7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (2-(4-fluorphenyl)ethyl)amide

Guidance literature:: Multi-step reaction with 5 steps

1: piperidine; acetic acid / ethanol / 16 h / Reflux; Inert atmosphere

2: hydrogenchloride; water / ethanol / 60 °C

3: thionyl chloride / toluene / 3 h / Reflux; Inert atmosphere

4: triethylamine / dichloromethane / 16 h / 0 - 20 °C

5: pyridine hydrogenfluoride; sodium nitrite / 2 h / 20 - 85 °C

With piperidine; hydrogenchloride; thionyl chloride; water; pyridine hydrogenfluoride; acetic acid; triethylamine; sodium nitrite; In ethanol; dichloromethane; toluene;
DOI:10.1016/j.bmc.2011.07.062