7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid 2-(4-amino-phenyl)ethylamide

Base Information

Chemical Name:7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid 2-(4-amino-phenyl)ethylamide
CAS No.:1338350-75-6
Molecular Formula:C₂₃H₂₇N₃O₄
Molecular Weight:409.485
Hs Code.:

Synonyms:7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid 2-(4-amino-phenyl)ethylamide

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Chemical Property of 7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid 2-(4-amino-phenyl)ethylamide

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Technology Process of 7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid 2-(4-amino-phenyl)ethylamide

There total 7 articles about 7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid 2-(4-amino-phenyl)ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 13472-00-9
p-Aminophenethylamine

: 1338350-70-1
C₁₅H₁₆ClNO₄

: 1338350-75-6
7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid 2-(4-amino-phenyl)ethylamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h;
DOI:10.1016/j.bmc.2011.07.062

Reference yield:

: 621-59-0
isovanillin

: 1338350-75-6
7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid 2-(4-amino-phenyl)ethylamide

Guidance literature:: Multi-step reaction with 7 steps

1: nitronium tetrafluoborate / dichloromethane / 24 h / -20 °C / Inert atmosphere

2: caesium carbonate; sodium iodide / N,N-dimethyl-formamide / 25 h / 20 - 80 °C / Inert atmosphere

3: hydrogenchloride; iron; acetic acid / water; ethyl acetate / 0.25 h / Reflux

4: piperidine; acetic acid / ethanol / 16 h / Reflux; Inert atmosphere

5: hydrogenchloride; water / ethanol / 60 °C

6: thionyl chloride / toluene / 3 h / Reflux; Inert atmosphere

7: triethylamine / dichloromethane / 16 h / 0 - 20 °C

With piperidine; hydrogenchloride; thionyl chloride; nitronium tetrafluoborate; water; iron; caesium carbonate; acetic acid; triethylamine; sodium iodide; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.07.062

Reference yield:

: 282089-63-8
8-butoxy-7-methoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid

: 1338350-75-6
7-methoxy-8-butyloxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid 2-(4-amino-phenyl)ethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / toluene / 3 h / Reflux; Inert atmosphere

2: triethylamine / dichloromethane / 16 h / 0 - 20 °C

With thionyl chloride; triethylamine; In dichloromethane; toluene;
DOI:10.1016/j.bmc.2011.07.062