(E)-(R)-methyl 3-<2-ethyl>-4-hexenoate

Base Information

Chemical Name:(E)-(R)-methyl 3-<2-ethyl>-4-hexenoate
CAS No.:169220-12-6
Molecular Formula:C₂₁H₃₁NO₄
Molecular Weight:361.481
Hs Code.:

(E)-(R)-methyl 3-<2-<N-benzyl-N-(tert-butoxycarbonyl)amino>ethyl>-4-hexenoate

Synonyms:(E)-(R)-methyl 3-<2-ethyl>-4-hexenoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-(R)-methyl 3-<2-ethyl>-4-hexenoate

Chemical Property:

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Technology Process of (E)-(R)-methyl 3-<2-ethyl>-4-hexenoate

There total 8 articles about (E)-(R)-methyl 3-<2-ethyl>-4-hexenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 169220-12-6
(E)-(R)-methyl 3-<2-ethyl>-4-hexenoate

Guidance literature:: Multi-step reaction with 7 steps

1: imidazole

2: NaH

3: aq. AcOH / tetrahydrofuran

4: (COCl)2, DMSO / CH₂Cl₂ / 0.42 h / -78 °C

5: 1.) LiBr, 2.) Et₃N / 1.) THF, RT, 5 min, 2.) THF, RT, overnight

6: oxazaborolidine, catecholborane / toluene / 21 h / -78 °C

7: propionic acid / toluene / 3 h / 115 °C

With 1H-imidazole; (S)-oxazaborolidine; oxalyl dichloride; sodium hydride; acetic acid; dimethyl sulfoxide; propionic acid; triethylamine; lithium bromide; benzo[1,3,2]dioxaborole; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ja00141a004

Reference yield:

: 1445-45-0
Trimethyl orthoacetate

: 169129-45-7
(E)-(R)-6--3-hexen-2-ol

: (E)-(S)-methyl 3-<2-ethyl>-4-hexenoate

: 169220-12-6
(E)-(R)-methyl 3-<2-ethyl>-4-hexenoate

Guidance literature:: With propionic acid; In toluene; at 115 ℃; for 3h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/ja00141a004

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 169220-12-6
(E)-(R)-methyl 3-<2-ethyl>-4-hexenoate

Guidance literature:: Multi-step reaction with 8 steps

1: NaOH

2: imidazole

3: NaH

4: aq. AcOH / tetrahydrofuran

5: (COCl)2, DMSO / CH₂Cl₂ / 0.42 h / -78 °C

6: 1.) LiBr, 2.) Et₃N / 1.) THF, RT, 5 min, 2.) THF, RT, overnight

7: oxazaborolidine, catecholborane / toluene / 21 h / -78 °C

8: propionic acid / toluene / 3 h / 115 °C

With 1H-imidazole; sodium hydroxide; (S)-oxazaborolidine; oxalyl dichloride; sodium hydride; acetic acid; dimethyl sulfoxide; propionic acid; triethylamine; lithium bromide; benzo[1,3,2]dioxaborole; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ja00141a004