3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one

Base Information

• Chemical Name: 3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one
• CAS No.: 60598-73-4
• Molecular Formula: C₁₆H₁₄N₂OS
• Molecular Weight: 282.366
• Mol file: 60598-73-4.mol

Synonyms:3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one

Chemical Property of 3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one

There total 8 articles about 3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one (14346-24-8) + phenylboronic acid (98-80-6) → 3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one (60598-73-4)

Guidance literature:

With copper diacetate; triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 1h; Solvent; Time; Catalytic behavior;

DOI:10.1016/j.bmc.2012.07.011

Reference yield: 40.0%

2-amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid phenyl-amide (60598-68-7) + orthoformic acid triethyl ester (122-51-0) → 3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one (60598-73-4)

Guidance literature:

With trichlorophosphate; In toluene; at 95 ℃; for 1h;

Reference yield:

cyanoacetanilide (621-03-4) → 3-phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one (60598-73-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 47 percent / CH₃COONH₄, CH₃COOH / benzene / 6 h / Heating

2: 44 percent / S, Et₂NH / ethanol / 3 h / 50 °C

3: 40 percent / POCl₃ / toluene / 1 h / 95 °C

With ammonium acetate; acetic acid; diethylamine; trichlorophosphate; In ethanol; toluene; benzene;

upstream raw materials:

2-amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid phenyl-amide

orthoformic acid triethyl ester

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

aniline