6-(2,6-difluoro-4-(3-methoxyoxetan-3-yl)phenyl)-5-fluoropicolinic acid

Base Information

• Chemical Name: 6-(2,6-difluoro-4-(3-methoxyoxetan-3-yl)phenyl)-5-fluoropicolinic acid
• CAS No.: 1395281-79-4
• Molecular Formula: C₁₆H₁₂F₃NO₄
• Molecular Weight: 339.271

Synonyms:6-(2,6-difluoro-4-(3-methoxyoxetan-3-yl)phenyl)-5-fluoropicolinic acid

Chemical Property of 6-(2,6-difluoro-4-(3-methoxyoxetan-3-yl)phenyl)-5-fluoropicolinic acid

Chemical Property:

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Technology Process of 6-(2,6-difluoro-4-(3-methoxyoxetan-3-yl)phenyl)-5-fluoropicolinic acid

There total 8 articles about 6-(2,6-difluoro-4-(3-methoxyoxetan-3-yl)phenyl)-5-fluoropicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

→ 6-(2,6-difluoro-4-(3-methoxyoxetan-3-yl)phenyl)-5-fluoropicolinic acid (1395281-79-4)

Guidance literature:

Reference yield:

2-bromo-3-fluoro-6-methylpyridine (374633-36-0) → 6-(2,6-difluoro-4-(3-methoxyoxetan-3-yl)phenyl)-5-fluoropicolinic acid (1395281-79-4)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium permanganate / water

2: sulfuric acid / methanol

4: NaH / N,N-dimethyl-formamide

With potassium permanganate; NaH; sulfuric acid; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

methyl 6-bromo-5-fluoropyridine-2-carboxylate (1210419-26-3) → 6-(2,6-difluoro-4-(3-methoxyoxetan-3-yl)phenyl)-5-fluoropicolinic acid (1395281-79-4)

Guidance literature:

Multi-step reaction with 3 steps

2: NaH / N,N-dimethyl-formamide

With NaH; In N,N-dimethyl-formamide;

upstream raw materials:

3,5-difluorobromobenzene

2-bromo-3-fluoro-6-methylpyridine

6-bromo-5-fluoro-pyridine-2-carboxylic acid

methyl 6-bromo-5-fluoropyridine-2-carboxylate

Downstream raw materials:

N-(5-((2S,5R,6S)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-6-(2,6-difluoro-4-(3-methoxyoxetan-3-yl)phenyl)-5-fluoropicolinamide

N-(5-((2S,5R,6R)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-6-(2,6-difluoro-4-(3-methoxyoxetan-3-yl)phenyl)-5-fluoropicolinamide

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