5-[1-(benzo[b]thien-2-yl)ethyl]-2-(O-dimethylthiocarbamate)benzaldehyde

Base Information

Chemical Name:5-[1-(benzo[b]thien-2-yl)ethyl]-2-(O-dimethylthiocarbamate)benzaldehyde
CAS No.:281191-12-6
Molecular Formula:C₂₀H₁₉NO₂S₂
Molecular Weight:369.508
Hs Code.:

Synonyms:5-[1-(benzo[b]thien-2-yl)ethyl]-2-(O-dimethylthiocarbamate)benzaldehyde

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Chemical Property of 5-[1-(benzo[b]thien-2-yl)ethyl]-2-(O-dimethylthiocarbamate)benzaldehyde

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Technology Process of 5-[1-(benzo[b]thien-2-yl)ethyl]-2-(O-dimethylthiocarbamate)benzaldehyde

There total 5 articles about 5-[1-(benzo[b]thien-2-yl)ethyl]-2-(O-dimethylthiocarbamate)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 16420-13-6
N,N-Dimethylthiocarbamoyl chloride

: 281191-11-5
5-[1-(benzo[b]thien-2-yl)ethyl]-2-hydroxybenzaldehyde

: 281191-12-6
5-[1-(benzo[b]thien-2-yl)ethyl]-2-(O-dimethylthiocarbamate)benzaldehyde

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.3987/com-00-8848

Reference yield:

: 51868-95-2
1-(benzo[b]thiophen-2-yl)ethanol

: 281191-12-6
5-[1-(benzo[b]thien-2-yl)ethyl]-2-(O-dimethylthiocarbamate)benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / BF₃*OEt₂ / CH₂Cl₂ / 0.25 h / 0 - 5 °C

2: 23 percent / powd. NaOH / aq. ethanol / 0.67 h / 70 °C

3: 66 percent / aq. KOH / tetrahydrofuran / 2 h / 20 °C

With potassium hydroxide; sodium hydroxide; boron trifluoride diethyl etherate; In tetrahydrofuran; ethanol; dichloromethane; 1: Condensation / 2: Formylation / 3: Esterification;
DOI:10.3987/com-00-8848

Reference yield:

: 22720-75-8
2-acetyl benzo[b]thiophene

: 281191-12-6
5-[1-(benzo[b]thien-2-yl)ethyl]-2-(O-dimethylthiocarbamate)benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / NaBH₄ / methanol / 0.33 h / 0 °C

2: 56 percent / BF₃*OEt₂ / CH₂Cl₂ / 0.25 h / 0 - 5 °C

3: 23 percent / powd. NaOH / aq. ethanol / 0.67 h / 70 °C

4: 66 percent / aq. KOH / tetrahydrofuran / 2 h / 20 °C

With potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1: Reduction / 2: Condensation / 3: Formylation / 4: Esterification;
DOI:10.3987/com-00-8848