4-{[3-(4-cyanophenyl)-2-methyloxiran-2-yl]carbonyl}morpholine

Base Information

• Chemical Name: 4-{[3-(4-cyanophenyl)-2-methyloxiran-2-yl]carbonyl}morpholine
• CAS No.: 1207506-67-9
• Molecular Formula: C₁₅H₁₆N₂O₃
• Molecular Weight: 272.304
• Mol file: 1207506-67-9.mol

Synonyms:4-{[3-(4-cyanophenyl)-2-methyloxiran-2-yl]carbonyl}morpholine

Chemical Property of 4-{[3-(4-cyanophenyl)-2-methyloxiran-2-yl]carbonyl}morpholine

Chemical Property:

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Technology Process of 4-{[3-(4-cyanophenyl)-2-methyloxiran-2-yl]carbonyl}morpholine

There total 1 articles about 4-{[3-(4-cyanophenyl)-2-methyloxiran-2-yl]carbonyl}morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-1-(4-morpholino)propan-1-one (54022-76-3) + 4-cyanobenzaldehyde (105-07-7) → 4-{[3-(4-cyanophenyl)-2-methyloxiran-2-yl]carbonyl}morpholine (1207506-67-9)

Guidance literature:

2-chloro-1-(4-morpholino)propan-1-one; With lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.166667h;

4-cyanobenzaldehyde; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃;

DOI:10.1002/adsc.200900257

Reference yield: 84.0%

4-{[3-(4-cyanophenyl)-2-methyloxiran-2-yl]carbonyl}morpholine (1207506-67-9) → 4-[3-(4-cyanophenyl)-2-hydroxy-2-methyl-1-oxopropyl]morpholine (1207506-78-2)

Guidance literature:

With Highly Active Manganese (Mn*); In tetrahydrofuran; at 20 ℃; for 2.5h; regioselective reaction; Inert atmosphere;

DOI:10.1002/adsc.200900257

upstream raw materials:

2-chloro-1-(4-morpholino)propan-1-one

4-cyanobenzaldehyde

Downstream raw materials:

4-[3-(4-cyanophenyl)-2-hydroxy-2-methyl-1-oxopropyl]morpholine