54022-76-3Relevant articles and documents
LSD1 Inhibitors
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Paragraph 0449; 0450, (2017/07/14)
The present invention relates to compounds that inhibit LSD1 activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.
Hiyama reactions of activated and unactivated secondary alkyl halides catalyzed by a nickel/norephedrine complex
Strotman, Neil A.,Sommer, Stefan,Fu, Gregory C.
, p. 3556 - 3558 (2008/02/14)
(Chemical Equation Presented) An active partner: Nickel in combination with an amino alcohol ligand (norephedrine) was found to provide the most versatile and efficient catalyst for Hiyama cross-coupling reactions of alkyl electrophiles that has been described to date. Unprecedented Hiyama reactions of activated secondary alkyl bromides were achieved, as were the first Hiyama couplings of (activated) alkyl chlorides (see scheme, X = Br, Cl; HMDS = 1,1,1,3,3,3-hexamethyldisilazane, DMA = N,N-dimethylacetamide).