54022-76-3

Upstream product

• 110-91-8 morpholine 
• 7623-09-8 2-chloropropionyl chloride 
• 598-78-7 (R,S)-2-chloropropionic acid 

Downstream Products

• 1198335-31-7 2,4-dimethyl-1-morpholino-3-(tosylamino)hexan-1-one 
• 1198335-28-2 2-methyl-1-morpholino-4-phenyl-3-(tosylamino)butan-1-one 
• 1207506-67-9 4-{[3-(4-cyanophenyl)-2-methyloxiran-2-yl]carbonyl}morpholine 
• 1004-14-4 4-isopropyl-morpholine 
• 5117-12-4 N-Acryloylmorpholine 

Relevant academic research and scientific papers

LSD1 Inhibitors

The present invention relates to compounds that inhibit LSD1 activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

Based on 2- halogen propionyl chloride method of synthesizing acryloyl morpholine (by machine translation)

The invention discloses a based on 2- halogen propionyl chloride method of synthesizing acryloyl morpholine, this invention offers a based on 2- halogen propionyl chloride and morpholine generating [...] reaction to form intermediate product 2- halogen propionyl morphline, and sodium in ethanol with a defoaming reaction containing double bond monomer acryloyl morpholine. The invention synthetic method of acryloyl morpholine, the raw materials used are cheap, the structure is stable, synthetic intermediates containing no chirpy group, side reaction is not easy to occur, the yield and the purity of the final product are relatively high. The present invention provides synthetic method process is simple, with the prospects for industrial large-scale production. (by machine translation)

Hiyama reactions of activated and unactivated secondary alkyl halides catalyzed by a nickel/norephedrine complex

(Chemical Equation Presented) An active partner: Nickel in combination with an amino alcohol ligand (norephedrine) was found to provide the most versatile and efficient catalyst for Hiyama cross-coupling reactions of alkyl electrophiles that has been described to date. Unprecedented Hiyama reactions of activated secondary alkyl bromides were achieved, as were the first Hiyama couplings of (activated) alkyl chlorides (see scheme, X = Br, Cl; HMDS = 1,1,1,3,3,3-hexamethyldisilazane, DMA = N,N-dimethylacetamide).