acetic acid 1-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indazol-3-yl]-2,2,2-trifluoro-1-methylethyl ester

Base Information

Chemical Name:acetic acid 1-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indazol-3-yl]-2,2,2-trifluoro-1-methylethyl ester
CAS No.:1040502-39-3
Molecular Formula:C₁₉H₁₂Cl₂F₆N₂O₂
Molecular Weight:485.213
Hs Code.:

Synonyms:acetic acid 1-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indazol-3-yl]-2,2,2-trifluoro-1-methylethyl ester

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Chemical Property of acetic acid 1-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indazol-3-yl]-2,2,2-trifluoro-1-methylethyl ester

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Technology Process of acetic acid 1-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indazol-3-yl]-2,2,2-trifluoro-1-methylethyl ester

There total 3 articles about acetic acid 1-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indazol-3-yl]-2,2,2-trifluoro-1-methylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1034620-66-0
2-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indazol-3-yl]-1,1,1-trifluoropropan-2-ol

: 75-36-5
acetyl chloride

: 1040502-39-3
acetic acid 1-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indazol-3-yl]-2,2,2-trifluoro-1-methylethyl ester

Guidance literature:: 2-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indazol-3-yl]-1,1,1-trifluoropropan-2-ol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

acetyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 40598-94-5
3-bromo-1H-indazole

: 1040502-39-3
acetic acid 1-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indazol-3-yl]-2,2,2-trifluoro-1-methylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexanes; diethyl ether / 0.08 h / -78 °C

1.2: 0.25 h / -78 - -70 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 21 h / 90 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C

3.2: 20 h / 20 °C

With n-butyllithium; sodium hydride; potassium carbonate; In hexanes; diethyl ether; N,N-dimethyl-formamide;

Reference yield:

: 1040502-35-9
1,1,1-trifluoro-2-(1H-indazol-3-yl)propan-2-ol

: 1040502-39-3
acetic acid 1-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indazol-3-yl]-2,2,2-trifluoro-1-methylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 21 h / 90 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C

2.2: 20 h / 20 °C

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide;