N-(1,1-dimethylethyl)-2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide hydrochloride salt

Base Information

Chemical Name:N-(1,1-dimethylethyl)-2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide hydrochloride salt
CAS No.:1192313-09-9
Molecular Formula:C₂₇H₃₃F₄N₅O₃*ClH
Molecular Weight:588.045
Hs Code.:

N-(1,1-dimethylethyl)-2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide hydrochloride salt

Synonyms:N-(1,1-dimethylethyl)-2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide hydrochloride salt

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Chemical Property of N-(1,1-dimethylethyl)-2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide hydrochloride salt

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Technology Process of N-(1,1-dimethylethyl)-2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide hydrochloride salt

There total 5 articles about N-(1,1-dimethylethyl)-2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-89-4
piperidine

: C₂₃H₂₆F₄N₄O₅S

: 1192313-09-9
N-(1,1-dimethylethyl)-2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide hydrochloride salt

Guidance literature:: piperidine; C₂₃H₂₆F₄N₄O₅S; With potassium carbonate; In acetonitrile; at 80 ℃; for 1.5h;

With hydrogenchloride; In diethyl ether; dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

: 110-89-4
piperidine

: C₂₃H₂₆F₄N₄O₆S

: 1192313-09-9
N-(1,1-dimethylethyl)-2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide hydrochloride salt

Guidance literature:: piperidine; C₂₃H₂₆F₄N₄O₆S; With potassium carbonate; In acetonitrile; at 80 ℃; for 1.5h;

With hydrogenchloride; In diethyl ether; dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

: 1192313-59-9
3-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl}oxy)propyl acetate

: 1192313-09-9
N-(1,1-dimethylethyl)-2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide hydrochloride salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 80 °C

2.1: lithium hydroxide / tetrahydrofuran / 20 °C

3.1: triethylamine / dichloromethane / 1 h / 20 °C

4.1: potassium carbonate / acetonitrile / 1.5 h / 80 °C

4.2: 0.5 h / 0 °C

With potassium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile;