5,5-bis<<(benzenesulfonyl)oxy>methyl>spirohexane

Base Information

• Chemical Name: 5,5-bis<<(benzenesulfonyl)oxy>methyl>spirohexane
• CAS No.: 173203-64-0
• Molecular Formula: C₂₀H₂₂O₆S₂
• Molecular Weight: 422.523
• Mol file: 173203-64-0.mol

Synonyms:5,5-bis<<(benzenesulfonyl)oxy>methyl>spirohexane

Chemical Property of 5,5-bis<<(benzenesulfonyl)oxy>methyl>spirohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 5,5-bis<<(benzenesulfonyl)oxy>methyl>spirohexane

There total 3 articles about 5,5-bis<<(benzenesulfonyl)oxy>methyl>spirohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

benzenesulfonyl chloride (98-09-9) + 5,5-bis(hydroxymethyl)spirohexane (173203-63-9) → 5,5-bis<<(benzenesulfonyl)oxy>methyl>spirohexane (173203-64-0)

Guidance literature:

With pyridine; at -5 ℃; for 12h;

DOI:10.1021/ja00153a006

Reference yield:

1,1-bis(bromomethyl)cyclopropane (29086-41-7) → 5,5-bis<<(benzenesulfonyl)oxy>methyl>spirohexane (173203-64-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 32 percent / K₂CO₃ / dimethylsulfoxide / 15 h / 70 °C

2: 99 percent / LiAlH₄ / diethyl ether / 1 h / Heating

3: 65 percent / pyridine / 12 h / -5 °C

With pyridine; lithium aluminium tetrahydride; potassium carbonate; In diethyl ether; dimethyl sulfoxide;

DOI:10.1021/ja00153a006

Reference yield:

diethyl spirohexane-5,5-dicarboxylate (173203-62-8) → 5,5-bis<<(benzenesulfonyl)oxy>methyl>spirohexane (173203-64-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / LiAlH₄ / diethyl ether / 1 h / Heating

2: 65 percent / pyridine / 12 h / -5 °C

With pyridine; lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1021/ja00153a006

upstream raw materials:

benzenesulfonyl chloride

5,5-bis(hydroxymethyl)spirohexane

1,1-bis(bromomethyl)cyclopropane

diethyl spirohexane-5,5-dicarboxylate

Downstream raw materials:

Dispiro <2.1.2.1>octan

Refernces