(S)-2-methylsulfonyloxy-1-(4-methylphenyl)-1-propanone dimethyl acetal

Base Information

• Chemical Name: (S)-2-methylsulfonyloxy-1-(4-methylphenyl)-1-propanone dimethyl acetal
• CAS No.: 103593-52-8
• Molecular Formula: C₁₃H₂₀O₅S
• Molecular Weight: 288.365
• Mol file: 103593-52-8.mol

Synonyms:(S)-2-methylsulfonyloxy-1-(4-methylphenyl)-1-propanone dimethyl acetal

Chemical Property of (S)-2-methylsulfonyloxy-1-(4-methylphenyl)-1-propanone dimethyl acetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-methylsulfonyloxy-1-(4-methylphenyl)-1-propanone dimethyl acetal

There total 5 articles about (S)-2-methylsulfonyloxy-1-(4-methylphenyl)-1-propanone dimethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanesulfonyl chloride (124-63-0) + (S)-2-hydroxy-1-(4-methylphenyl)-1-propanone dimethyl acetal (111197-83-2) → (S)-2-methylsulfonyloxy-1-(4-methylphenyl)-1-propanone dimethyl acetal (103593-52-8)

Guidance literature:

With pyridine; for 12h; Ambient temperature;

DOI:10.1246/bcsj.60.1027

Reference yield:

(S)-2-methoxymethoxy-1-(4-methylphenyl)-1-propanone (111199-11-2) → (S)-2-methylsulfonyloxy-1-(4-methylphenyl)-1-propanone dimethyl acetal (103593-52-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / 1M HCl / methanol / 6 h / 60 °C

2: 82 percent / methanesulfonic acid / methanol / 1 h / ice cooling

3: 99 percent / pyridine / 12 h / Ambient temperature

With pyridine; hydrogenchloride; methanesulfonic acid; In methanol;

DOI:10.1246/bcsj.60.1027

Reference yield:

(S)-2-hydroxy-1-(4-methylphenyl)-1-propanone (111197-79-6) → (S)-2-methylsulfonyloxy-1-(4-methylphenyl)-1-propanone dimethyl acetal (103593-52-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / methanesulfonic acid / methanol / 1 h / ice cooling

2: 99 percent / pyridine / 12 h / Ambient temperature

With pyridine; methanesulfonic acid; In methanol;

DOI:10.1246/bcsj.60.1027

upstream raw materials:

(S)-2-O-(1-ethoxyethyl)-N,N-dimethyllactamide

para-methylphenylmagnesium bromide

methanesulfonyl chloride

(S)-2-hydroxy-1-(4-methylphenyl)-1-propanone dimethyl acetal

Downstream raw materials:

1-((S)-2,2-Dimethoxy-1-methyl-ethyl)-4-methyl-benzene

methyl (S)-2-(4-methylphenyl)propionate