(1S,3R)-3-((1Z,3Z,5R,7R,8R,9E)-8-(2-(allyloxycarbonylamino)ethyl)-7-(bis(allyloxy)phosphoryloxy)-10-((2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-5,8-dihydroxydeca-1,3,9-trienyl)cyclohexyl isobutyrate

Base Information

Chemical Name:(1S,3R)-3-((1Z,3Z,5R,7R,8R,9E)-8-(2-(allyloxycarbonylamino)ethyl)-7-(bis(allyloxy)phosphoryloxy)-10-((2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-5,8-dihydroxydeca-1,3,9-trienyl)cyclohexyl isobutyrate
CAS No.:1164115-05-2
Molecular Formula:C₃₉H₅₈NO₁₂P
Molecular Weight:763.863
Hs Code.:

(1S,3R)-3-((1Z,3Z,5R,7R,8R,9E)-8-(2-(allyloxycarbonylamino)ethyl)-7-(bis(allyloxy)phosphoryloxy)-10-((2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-5,8-dihydroxydeca-1,3,9-trienyl)cyclohexyl isobutyrate

Synonyms:(1S,3R)-3-((1Z,3Z,5R,7R,8R,9E)-8-(2-(allyloxycarbonylamino)ethyl)-7-(bis(allyloxy)phosphoryloxy)-10-((2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-5,8-dihydroxydeca-1,3,9-trienyl)cyclohexyl isobutyrate

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Chemical Property of (1S,3R)-3-((1Z,3Z,5R,7R,8R,9E)-8-(2-(allyloxycarbonylamino)ethyl)-7-(bis(allyloxy)phosphoryloxy)-10-((2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-5,8-dihydroxydeca-1,3,9-trienyl)cyclohexyl isobutyrate

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Technology Process of (1S,3R)-3-((1Z,3Z,5R,7R,8R,9E)-8-(2-(allyloxycarbonylamino)ethyl)-7-(bis(allyloxy)phosphoryloxy)-10-((2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-5,8-dihydroxydeca-1,3,9-trienyl)cyclohexyl isobutyrate

There total 2 articles about (1S,3R)-3-((1Z,3Z,5R,7R,8R,9E)-8-(2-(allyloxycarbonylamino)ethyl)-7-(bis(allyloxy)phosphoryloxy)-10-((2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-5,8-dihydroxydeca-1,3,9-trienyl)cyclohexyl isobutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1164114-89-9
(1S,3R)-3-((Z)-2-(tributylstannyl)vinyl)cyclohexyl isobutyrate

: 1164114-88-8
allyl-(3R,4R,6R,Z)-4-(bis(allyloxy)phosphoryloxy)-3-((E)-2-((2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)vinyl)-3,6-dihydroxy-8-iodooct-7-enylcarbamate

: 1164115-05-2
(1S,3R)-3-((1Z,3Z,5R,7R,8R,9E)-8-(2-(allyloxycarbonylamino)ethyl)-7-(bis(allyloxy)phosphoryloxy)-10-((2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-5,8-dihydroxydeca-1,3,9-trienyl)cyclohexyl isobutyrate

Guidance literature:: With copper(I) thiophene-2-carboxylate; In 1-methyl-pyrrolidin-2-one; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol900757k

Reference yield:

: 1234580-14-3
(1'Z,1S,3R)-1-tert-butyldimethylsiloxy-3-(2'-iodovinyl)-cyclohexane

: 1164114-88-8
allyl-(3R,4R,6R,Z)-4-(bis(allyloxy)phosphoryloxy)-3-((E)-2-((2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)vinyl)-3,6-dihydroxy-8-iodooct-7-enylcarbamate

: 79-31-2
isobutyric Acid

: 1164115-05-2
(1S,3R)-3-((1Z,3Z,5R,7R,8R,9E)-8-(2-(allyloxycarbonylamino)ethyl)-7-(bis(allyloxy)phosphoryloxy)-10-((2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-5,8-dihydroxydeca-1,3,9-trienyl)cyclohexyl isobutyrate

Guidance literature:: (1'Z,1S,3R)-1-tert-butyldimethylsiloxy-3-(2'-iodovinyl)-cyclohexane; With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; for 0.25h; Inert atmosphere;

With tributyltin chloride; In diethyl ether; pentane; at -78 ℃; Inert atmosphere;

allyl-(3R,4R,6R,Z)-4-(bis(allyloxy)phosphoryloxy)-3-((E)-2-((2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)vinyl)-3,6-dihydroxy-8-iodooct-7-enylcarbamate; isobutyric Acid; Further stages;
DOI:10.1021/ol900757k

Reference yield: 51.0%

: 1164115-05-2
(1S,3R)-3-((1Z,3Z,5R,7R,8R,9E)-8-(2-(allyloxycarbonylamino)ethyl)-7-(bis(allyloxy)phosphoryloxy)-10-((2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-5,8-dihydroxydeca-1,3,9-trienyl)cyclohexyl isobutyrate

: 159991-67-0,122856-25-1
phoslactomycin A

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; formic acid; triethylamine; In tetrahydrofuran; at 50 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ol900757k DOI:10.1002/chem.201000104