3-(bromomethyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-4-yl benzoate

Base Information

• Chemical Name: 3-(bromomethyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-4-yl benzoate
• CAS No.: 910916-63-1
• Molecular Formula: C₁₄H₁₆BrNO₃
• Molecular Weight: 326.19
• Mol file: 910916-63-1.mol

Synonyms:3-(bromomethyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-4-yl benzoate

Chemical Property of 3-(bromomethyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-4-yl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(bromomethyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-4-yl benzoate

There total 6 articles about 3-(bromomethyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-4-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-(benzoyloxy)-6,6-dimethyl-3-methylene-2-trimethylsilyloxy-2,3,5,6-tetrahydro-4H-[1,2]oxazine → 3-(bromomethyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-4-yl benzoate (910916-63-1)

Guidance literature:

With cobalt(II) bromide; In tetrahydrofuran; dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/ejoc.201403083

Reference yield: 68.0%

benzoic acid 3,6,6-trimethyl-2-oxo-5,6-dihydro-4H-1,2-oxazine-4-yl ester (742062-71-1) → 3-(bromomethyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-4-yl benzoate (910916-63-1)

Guidance literature:

benzoic acid 3,6,6-trimethyl-2-oxo-5,6-dihydro-4H-1,2-oxazine-4-yl ester; With trimethylsilyl bromide; triethylamine; In dichloromethane; at -80 ℃; for 1h;

With acetonitrile; In dichloromethane; at -30 ℃; for 3h; Further stages.;

DOI:10.1055/s-2006-958930

Reference yield:

trimethylsilyl bromide (2857-97-8) + benzoic acid 3,6,6-trimethyl-2-oxo-5,6-dihydro-4H-1,2-oxazine-4-yl ester (742062-71-1) → 3-(bromomethyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-4-yl benzoate (910916-63-1)

Guidance literature:

With triethylamine; In dichloromethane; at -80 - -30 ℃; for 5h;

DOI:10.1016/j.btre.2020.e00438

upstream raw materials:

benzoic acid 3,6,6-trimethyl-2-oxo-5,6-dihydro-4H-1,2-oxazine-4-yl ester

benzoic formic anhydride

benzoic acid (E)-2-nitroprop-1-enyl ester

trimethylsilyl bromide