tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-{[(2-hydroxyethyl)amino]methyl}-1,4-oxazepane-4-carboxylate

Base Information

Chemical Name:tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-{[(2-hydroxyethyl)amino]methyl}-1,4-oxazepane-4-carboxylate
CAS No.:1372187-67-1
Molecular Formula:C₁₉H₂₈Cl₂N₂O₄
Molecular Weight:419.348
Hs Code.:

Synonyms:tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-{[(2-hydroxyethyl)amino]methyl}-1,4-oxazepane-4-carboxylate

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Chemical Property of tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-{[(2-hydroxyethyl)amino]methyl}-1,4-oxazepane-4-carboxylate

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Technology Process of tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-{[(2-hydroxyethyl)amino]methyl}-1,4-oxazepane-4-carboxylate

There total 11 articles about tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-{[(2-hydroxyethyl)amino]methyl}-1,4-oxazepane-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372186-92-9
tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-{[(methylsulfonyl)oxy]methyl}-1,4-oxazepane-4-carboxylate

: 141-43-5
ethanolamine

: 1372187-67-1
tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-{[(2-hydroxyethyl)amino]methyl}-1,4-oxazepane-4-carboxylate

Guidance literature:: In ethanol; at 80 ℃;

Reference yield:

: 1372189-39-3
tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-(hydroxymethyl)-1,4-oxazepane-4-carboxylate

: 1372187-67-1
tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-{[(2-hydroxyethyl)amino]methyl}-1,4-oxazepane-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 2 h / Cooling with ice

2: ethanol / 80 °C

With triethylamine; In tetrahydrofuran; ethanol;

Reference yield:

: 6287-38-3
3,4-dichlorobenzaldehyde

: 1372187-67-1
tert-butyl (6R,7R)-7-(3,4-dichlorophenyl)-6-{[(2-hydroxyethyl)amino]methyl}-1,4-oxazepane-4-carboxylate

Guidance literature:: Multi-step reaction with 11 steps

1.1: 1,4-diaza-bicyclo[2.2.2]octane / acetonitrile / 48 h / 10 - 35 °C

2.1: triethylamine / methanol / 72 h / 10 - 35 °C

3.1: calcium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 2 h / 35 °C / Cooling with ice

3.2: 0.5 h

4.1: 1H-imidazole / tetrahydrofuran / 2 h / 35 °C / Cooling with ice

5.1: triethylamine / tetrahydrofuran / 1.5 h / 0 °C

6.1: sodium t-butanolate / tetrahydrofuran / 2 h / 35 °C / Cooling with ice

7.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether; tetrahydrofuran / 3 h / -78 - 0 °C / Inert atmosphere

7.2: 2 h / -78 - 35 °C

8.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 0.25 h / 10 - 35 °C

8.2: 18 h / 80 °C

8.3: 2 h / 35 °C / Cooling with ice

9.1: CHIRALPAK AD / hexane; ethanol / Resolution of racemate

10.1: triethylamine / tetrahydrofuran / 2 h / Cooling with ice

11.1: ethanol / 80 °C

With 1,4-diaza-bicyclo[2.2.2]octane; 1H-imidazole; aluminum (III) chloride; sodium tetrahydroborate; lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; triethylamine; calcium chloride; sodium t-butanolate; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; acetonitrile;