4-(4-methanesulfonylphenyl)-3-(4-methylphenyl)-2,5-dihydrofuran-2-one

Base Information

• Chemical Name: 4-(4-methanesulfonylphenyl)-3-(4-methylphenyl)-2,5-dihydrofuran-2-one
• CAS No.: 959003-56-6
• Molecular Formula: C₁₈H₁₆O₄S
• Molecular Weight: 328.389
• Mol file: 959003-56-6.mol

Synonyms:4-(4-methanesulfonylphenyl)-3-(4-methylphenyl)-2,5-dihydrofuran-2-one

Chemical Property of 4-(4-methanesulfonylphenyl)-3-(4-methylphenyl)-2,5-dihydrofuran-2-one

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-methanesulfonylphenyl)-3-(4-methylphenyl)-2,5-dihydrofuran-2-one

There total 8 articles about 4-(4-methanesulfonylphenyl)-3-(4-methylphenyl)-2,5-dihydrofuran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.1%

4-tolylacetic acid (622-47-9) + α,α-dibromo-4-methanesulfonylacetophenone (85976-24-5) → 4-(4-methanesulfonylphenyl)-3-(4-methylphenyl)-2,5-dihydrofuran-2-one (959003-56-6)

Guidance literature:

With triethylamine; In acetonitrile; at 78 - 82 ℃; for 1h; Reagent/catalyst;

Reference yield: 63.0%

4-tolylacetic acid (622-47-9) + 2-bromo-1-(4-methanesulfonylphenyl)ethanone (50413-24-6) → 4-(4-methanesulfonylphenyl)-3-(4-methylphenyl)-2,5-dihydrofuran-2-one (959003-56-6)

Guidance literature:

4-tolylacetic acid; 2-bromo-1-(4-methanesulfonylphenyl)ethanone; With triethylamine; In acetonitrile; at 25 ℃; for 1h; Inert atmosphere;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.05.017

Reference yield: 61.0%

4-(4-(methylthio)phenyl)-3-(p-tolyl)furan-2(5H)-one → 4-(4-methanesulfonylphenyl)-3-(4-methylphenyl)-2,5-dihydrofuran-2-one (959003-56-6)

Guidance literature:

With oxygen; uranyl(VI) acetate dihydrate; In o-xylene; water; acetonitrile; at 20 ℃; under 760.051 Torr; Schlenk technique; Irradiation;

DOI:10.1002/anie.201906080

upstream raw materials:

4-tolylacetic acid

2-bromo-1-(4-methanesulfonylphenyl)ethanone

C₁₈H₁₈O₅S

α,α-dibromo-4-methanesulfonylacetophenone

Downstream raw materials:

3-(4-bromomethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one

3-[4-(hydroxymethyl)phenyl]-4-[4-(methylsulfonyl)phenyl]furan-2(5H)-one

Imrecoxib