(2R,3R)-3-fluoro-3-{2-[(S)-p-tolylsulfinyl]phenyl}-2-(4-tolyl)-prop-1-yl phenyl sulfone

Base Information

• Chemical Name: (2R,3R)-3-fluoro-3-{2-[(S)-p-tolylsulfinyl]phenyl}-2-(4-tolyl)-prop-1-yl phenyl sulfone
• CAS No.: 1363721-83-8
• Molecular Formula: C₂₉H₂₇FO₃S₂
• Molecular Weight: 506.662
• Mol file: 1363721-83-8.mol

Synonyms:(2R,3R)-3-fluoro-3-{2-[(S)-p-tolylsulfinyl]phenyl}-2-(4-tolyl)-prop-1-yl phenyl sulfone

Chemical Property of (2R,3R)-3-fluoro-3-{2-[(S)-p-tolylsulfinyl]phenyl}-2-(4-tolyl)-prop-1-yl phenyl sulfone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R)-3-fluoro-3-{2-[(S)-p-tolylsulfinyl]phenyl}-2-(4-tolyl)-prop-1-yl phenyl sulfone

There total 2 articles about (2R,3R)-3-fluoro-3-{2-[(S)-p-tolylsulfinyl]phenyl}-2-(4-tolyl)-prop-1-yl phenyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C15H14O2S (101093-66-7) + 1-(fluoromethyl)-2-[(S)-p-tolylsulfinyl]benzene (1311404-00-8) → (2R,3R)-3-fluoro-3-{2-[(S)-p-tolylsulfinyl]phenyl}-2-(4-tolyl)-prop-1-yl phenyl sulfone (1363721-83-8) + (2S,3R)-3-fluoro-3-{2-[(S)-p-tolylsulfinyl]phenyl}-2-(4-tolyl)-prop-1-yl phenyl sulfone (1363721-93-0)

Guidance literature:

1-(fluoromethyl)-2-[(S)-p-tolylsulfinyl]benzene; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h; Inert atmosphere;

C₁₅H₁₄O₂S; In tetrahydrofuran; hexane; at -78 ℃; for 0.0166667h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/jo300174k

Reference yield:

C20H18O4S2 → (2R,3R)-3-fluoro-3-{2-[(S)-p-tolylsulfinyl]phenyl}-2-(4-tolyl)-prop-1-yl phenyl sulfone (1363721-83-8) + (2S,3R)-3-fluoro-3-{2-[(S)-p-tolylsulfinyl]phenyl}-2-(4-tolyl)-prop-1-yl phenyl sulfone (1363721-93-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: cesium fluoride / acetonitrile / Ionic liquid; Inert atmosphere

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.08 h / -78 °C / Inert atmosphere

2.2: 0.02 h / -78 °C / Inert atmosphere

With n-butyllithium; diisopropylamine; cesium fluoride; In tetrahydrofuran; hexane; acetonitrile; 2.1: Michael condensation / 2.2: Michael condensation;

DOI:10.1021/jo300174k

upstream raw materials:

C₁₅H₁₄O₂S

1-(fluoromethyl)-2-[(S)-p-tolylsulfinyl]benzene