trichloroethyl thymidine-3' 3'-(mono-p-methoxytrityl)thymidine-5' phosphite

Base Information

• Chemical Name: trichloroethyl thymidine-3' 3'-(mono-p-methoxytrityl)thymidine-5' phosphite
• CAS No.: 73496-63-6
• Molecular Formula: C₄₂H₄₄Cl₃N₄O₁₂P
• Molecular Weight: 934.164

Synonyms:trichloroethyl thymidine-3' 3'-(mono-p-methoxytrityl)thymidine-5' phosphite

Chemical Property of trichloroethyl thymidine-3' 3'-(mono-p-methoxytrityl)thymidine-5' phosphite

Chemical Property:

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Technology Process of trichloroethyl thymidine-3' 3'-(mono-p-methoxytrityl)thymidine-5' phosphite

There total 3 articles about trichloroethyl thymidine-3' 3'-(mono-p-methoxytrityl)thymidine-5' phosphite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

trichloroethyl 5'-O-(phenoxyacetyl)thymidine-3' 3'-O-(mono-p-methoxytrityl)thymidine-5' phosphite (73496-62-5) → trichloroethyl thymidine-3' 3'-(mono-p-methoxytrityl)thymidine-5' phosphite (73496-63-6)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran; 1,4-dioxane; Ambient temperature;

DOI:10.1021/jo01301a035

Reference yield:

3'-O-(4-methoxytriphenylmethyl)thymidine (13084-61-2) → trichloroethyl thymidine-3' 3'-(mono-p-methoxytrityl)thymidine-5' phosphite (73496-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) pyridine / THF, -78 deg C

2: 79 percent / NH₄OH / dioxane; tetrahydrofuran / Ambient temperature

With pyridine; ammonium hydroxide; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jo01301a035

Reference yield:

5'-O-(phenoxyacetyl)thymidine (38558-16-6) → trichloroethyl thymidine-3' 3'-(mono-p-methoxytrityl)thymidine-5' phosphite (73496-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) pyridine / THF, -78 deg C

2: 79 percent / NH₄OH / dioxane; tetrahydrofuran / Ambient temperature

With pyridine; ammonium hydroxide; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jo01301a035

upstream raw materials:

trichloroethyl 5'-O-(phenoxyacetyl)thymidine-3' 3'-O-(mono-p-methoxytrityl)thymidine-5' phosphite

3'-O-(4-methoxytriphenylmethyl)thymidine

5'-O-(phenoxyacetyl)thymidine

Downstream raw materials:

C₆₂H₆₄Cl₆N₆O₂₀P₂

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