3'-O-(4-Methoxytrityl)thymidine

Base Information

Chemical Name:3'-O-(4-Methoxytrityl)thymidine
CAS No.:13084-61-2
Molecular Formula:C30H30N2O6
Molecular Weight:514.578
Hs Code.:
DSSTox Substance ID:DTXSID10429465
Nikkaji Number:J1.815.246K
Wikidata:Q82242505

Synonyms:3'-O-(4-Methoxytrityl)thymidine;ZINC08427414;13084-61-2;DTXSID10429465

Suppliers and Price of 3'-O-(4-Methoxytrityl)thymidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 3'-O-(4-Methoxytrityl)thymidine

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:514.21038668
Heavy Atom Count:38
Complexity:839

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)OC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=C(C=C5)OC
Isomeric SMILES:CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)OC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=C(C=C5)OC

Technology Process of 3'-O-(4-Methoxytrityl)thymidine

There total 6 articles about 3'-O-(4-Methoxytrityl)thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 14470-28-1
mono-4-methoxytrityl chloride

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

: 13084-61-2
3'-O-(4-methoxytriphenylmethyl)thymidine

Guidance literature:: thymidine; With pyridine; pivaloyl chloride; at 0 - 20 ℃; for 4h;

mono-4-methoxytrityl chloride; at 20 ℃; for 85h;
DOI:10.1002/ejoc.200700528

Reference yield:

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

: 13084-61-2
3'-O-(4-methoxytriphenylmethyl)thymidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) imidazole, 2.) pyridine / 1.) DMF, 5 h, 2.) reflux, 2 h

2: tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 1 h / Ambient temperature

With pyridine; 1H-imidazole; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1021/jm00171a039

Reference yield:

: 1-{(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidine-2,4-dione

: 13084-61-2
3'-O-(4-methoxytriphenylmethyl)thymidine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h; Yield given; Ambient temperature;
DOI:10.1021/jm00171a039