(+/-)-2-<1-(tetrahydropyran-2-yloxy)ethyl>-2-<4-(trifluoromethyl)phenyl>oxirane

Base Information

Chemical Name:(+/-)-2-<1-(tetrahydropyran-2-yloxy)ethyl>-2-<4-(trifluoromethyl)phenyl>oxirane
CAS No.:150803-04-6
Molecular Formula:C₁₆H₁₉F₃O₃
Molecular Weight:316.32
Hs Code.:

Synonyms:(+/-)-2-<1-(tetrahydropyran-2-yloxy)ethyl>-2-<4-(trifluoromethyl)phenyl>oxirane

Suppliers and Price of (+/-)-2-<1-(tetrahydropyran-2-yloxy)ethyl>-2-<4-(trifluoromethyl)phenyl>oxirane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+/-)-2-<1-(tetrahydropyran-2-yloxy)ethyl>-2-<4-(trifluoromethyl)phenyl>oxirane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+/-)-2-<1-(tetrahydropyran-2-yloxy)ethyl>-2-<4-(trifluoromethyl)phenyl>oxirane

There total 6 articles about (+/-)-2-<1-(tetrahydropyran-2-yloxy)ethyl>-2-<4-(trifluoromethyl)phenyl>oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1774-47-6
trimethylsulfoxonium iodide

: 158647-85-9
α-(tetrahydropyran-2-yloxy)-4-(trifluoromethyl)propiophenone

: 150803-04-6
(+/-)-2-<1-(tetrahydropyran-2-yloxy)ethyl>-2-<4-(trifluoromethyl)phenyl>oxirane

Guidance literature:: With sodium hydride; dimethyl sulfoxide; Yield given. Multistep reaction; 1.) 60 deg C, 1 h, 2.) 60 deg C, 2 h;
DOI:10.1021/jm00020a005

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 150803-04-6
(+/-)-2-<1-(tetrahydropyran-2-yloxy)ethyl>-2-<4-(trifluoromethyl)phenyl>oxirane

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / tetrahydrofuran / 2 h / Ambient temperature

2: 95 percent / PCC, celite / CH₂Cl₂ / 1 h / Ambient temperature

3: 93 percent / Br₂, AcOH / 2.5 h / 40 °C

4: 67 percent / aq. LiOH / dimethylformamide / 2 h / 0 °C

5: 28.6 g / pyridinium p-toluenesulfonate / CH₂Cl₂ / 24 h / Ambient temperature

6: 1.) NaH, DMSO / 1.) 60 deg C, 1 h, 2.) 60 deg C, 2 h

With lithium hydroxide; Celite; bromine; pyridinium p-toluenesulfonate; sodium hydride; acetic acid; dimethyl sulfoxide; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00020a005

Reference yield:

: 711-33-1
4-trifluoromethyl propiophenone

: 150803-04-6
(+/-)-2-<1-(tetrahydropyran-2-yloxy)ethyl>-2-<4-(trifluoromethyl)phenyl>oxirane

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / Br₂, AcOH / 2.5 h / 40 °C

2: 67 percent / aq. LiOH / dimethylformamide / 2 h / 0 °C

3: 28.6 g / pyridinium p-toluenesulfonate / CH₂Cl₂ / 24 h / Ambient temperature

4: 1.) NaH, DMSO / 1.) 60 deg C, 1 h, 2.) 60 deg C, 2 h

With lithium hydroxide; bromine; pyridinium p-toluenesulfonate; sodium hydride; acetic acid; dimethyl sulfoxide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00020a005