6-(2-fluoro-4-trifluoromethyl-phenyl)-N₄-(4-methoxy-phenyl)-pyrimidine-4,5-diamine

Base Information

• Chemical Name: 6-(2-fluoro-4-trifluoromethyl-phenyl)-N₄-(4-methoxy-phenyl)-pyrimidine-4,5-diamine
• CAS No.: 1220449-41-1
• Molecular Formula: C₁₈H₁₄F₄N₄O
• Molecular Weight: 378.329

Synonyms:6-(2-fluoro-4-trifluoromethyl-phenyl)-N₄-(4-methoxy-phenyl)-pyrimidine-4,5-diamine

Chemical Property of 6-(2-fluoro-4-trifluoromethyl-phenyl)-N₄-(4-methoxy-phenyl)-pyrimidine-4,5-diamine

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Technology Process of 6-(2-fluoro-4-trifluoromethyl-phenyl)-N₄-(4-methoxy-phenyl)-pyrimidine-4,5-diamine

There total 1 articles about 6-(2-fluoro-4-trifluoromethyl-phenyl)-N₄-(4-methoxy-phenyl)-pyrimidine-4,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

[6-(2-fluoro-4-trifluoromethyl-phenyl)-5-nitro-pyrimidin-4-yl]-(4-methoxy-phenyl)-amine (1220449-37-5) → 6-(2-fluoro-4-trifluoromethyl-phenyl)-N4-(4-methoxy-phenyl)-pyrimidine-4,5-diamine (1220449-41-1)

Guidance literature:

With hydrogen; Raney nickel; In methanol; at 20 ℃; for 4h;

Reference yield: 70.0%

6-(2-fluoro-4-trifluoromethyl-phenyl)-N4-(4-methoxy-phenyl)-pyrimidine-4,5-diamine (1220449-41-1) → 4-[5-amino-6-(2-fluoro-4-trifluoromethyl-phenyl)-pyrimidin-4-ylamino]-phenol (1220449-43-3)

Guidance literature:

6-(2-fluoro-4-trifluoromethyl-phenyl)-N₄-(4-methoxy-phenyl)-pyrimidine-4,5-diamine; With boron tribromide; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

With methanol; water; In dichloromethane; Inert atmosphere; Colling with ice-salt;

Reference yield: 63.0%

6-(2-fluoro-4-trifluoromethyl-phenyl)-N4-(4-methoxy-phenyl)-pyrimidine-4,5-diamine (1220449-41-1) + trimethyl orthoformate (149-73-5) → 6-(2-fluoro-4-trifluoromethylphenyl)-9-(4-methoxyphenyl)-9H-purine (1220633-97-5)

Guidance literature:

6-(2-fluoro-4-trifluoromethyl-phenyl)-N₄-(4-methoxy-phenyl)-pyrimidine-4,5-diamine; trimethyl orthoformate; With toluene-4-sulfonic acid; In tetrahydrofuran;

With sodium hydrogencarbonate; In tetrahydrofuran; water;

upstream raw materials:

[6-(2-fluoro-4-trifluoromethyl-phenyl)-5-nitro-pyrimidin-4-yl]-(4-methoxy-phenyl)-amine

Downstream raw materials:

4-[5-amino-6-(2-fluoro-4-trifluoromethyl-phenyl)-pyrimidin-4-ylamino]-phenol

6-(2-fluoro-4-trifluoromethylphenyl)-9-(4-methoxyphenyl)-7,9-dihydropurin-8-one

6-(2-fluoro-4-trifluoromethylphenyl)-9-(4-methoxyphenyl)-9H-purine

7-(2-fluoro-4-trifluoromethylphenyl)-3-(4-methoxyphenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

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