N-((2S,3R,4S,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-2-methoxy-3-methyltetrahydrofuran-3-yl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-((2S,3R,4S,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-2-methoxy-3-methyltetrahydrofuran-3-yl)-2,2,2-trifluoroacetamide
CAS No.:1439900-73-8
Molecular Formula:C₂₃H₂₆F₃NO₅
Molecular Weight:453.458
Hs Code.:

Synonyms:N-((2S,3R,4S,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-2-methoxy-3-methyltetrahydrofuran-3-yl)-2,2,2-trifluoroacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((2S,3R,4S,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-2-methoxy-3-methyltetrahydrofuran-3-yl)-2,2,2-trifluoroacetamide

Chemical Property:

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Technology Process of N-((2S,3R,4S,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-2-methoxy-3-methyltetrahydrofuran-3-yl)-2,2,2-trifluoroacetamide

There total 9 articles about N-((2S,3R,4S,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-2-methoxy-3-methyltetrahydrofuran-3-yl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: N-((2S,4S,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-2-methoxy-3-methyltetrahydrofuran-3-yl)-2-methylpropane-2-sulfinamide

: 407-25-0
trifluoroacetic anhydride

: 1439900-73-8
N-((2S,3R,4S,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-2-methoxy-3-methyltetrahydrofuran-3-yl)-2,2,2-trifluoroacetamide

Guidance literature:: N-((2S,4S,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-2-methoxy-3-methyltetrahydrofuran-3-yl)-2-methylpropane-2-sulfinamide; With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 1h;

trifluoroacetic anhydride; With pyridine; In dichloromethane; at -40 - 20 ℃; for 3h;

Reference yield: 60.0%

: 1439900-75-0
C₂₁H₂₇NO₄

: 407-25-0
trifluoroacetic anhydride

: 1439900-73-8
N-((2S,3R,4S,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-2-methoxy-3-methyltetrahydrofuran-3-yl)-2,2,2-trifluoroacetamide

Guidance literature:: With pyridine; In dichloromethane; at -40 - 20 ℃; for 3h;

Reference yield:

: 532-20-7,613-83-2,7261-25-8,7687-39-0,13221-22-2,14795-83-6,15761-67-8,20074-49-1,25545-03-3,25545-04-4,32445-75-3,34436-17-4,36441-93-7,36468-53-8,37110-85-3,37388-49-1,38029-69-5,40461-77-6,40461-89-0,41546-19-4,41546-20-7,41546-21-8,41546-26-3,41546-29-6,41546-30-9,41546-31-0,126872-16-0,131064-98-7
D-Ribose

: 1439900-73-8
N-((2S,3R,4S,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-2-methoxy-3-methyltetrahydrofuran-3-yl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / methanol / 24 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 °C

2.2: 16 h / 0 - 20 °C

3.1: tin(IV) chloride / dichloromethane / 24 h / 0 °C

4.1: Dess-Martin periodane / dichloromethane / 24 h / 0 - 20 °C

5.1: titanium(IV) tetraethanolate / tetrahydrofuran / 6 h / 20 - 60 °C

6.1: tetrahydrofuran / 0.5 h / -78 °C

7.1: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

8.1: pyridine / dichloromethane / 3 h / -40 - 20 °C

With pyridine; hydrogenchloride; titanium(IV) tetraethanolate; sulfuric acid; tin(IV) chloride; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;