4-({3-[4-(trifluoromethyl)phenyl]imidazo[1.2-a]pyrazin-6-yl}carbonyl)-3,4-dihydro-2H-1,4-benzoxazine-7-carbonitrile

Base Information

Chemical Name:4-({3-[4-(trifluoromethyl)phenyl]imidazo[1.2-a]pyrazin-6-yl}carbonyl)-3,4-dihydro-2H-1,4-benzoxazine-7-carbonitrile
CAS No.:1610670-55-7
Molecular Formula:C₂₃H₁₄F₃N₅O₂
Molecular Weight:449.392
Hs Code.:

Synonyms:4-({3-[4-(trifluoromethyl)phenyl]imidazo[1.2-a]pyrazin-6-yl}carbonyl)-3,4-dihydro-2H-1,4-benzoxazine-7-carbonitrile

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Chemical Property of 4-({3-[4-(trifluoromethyl)phenyl]imidazo[1.2-a]pyrazin-6-yl}carbonyl)-3,4-dihydro-2H-1,4-benzoxazine-7-carbonitrile

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Technology Process of 4-({3-[4-(trifluoromethyl)phenyl]imidazo[1.2-a]pyrazin-6-yl}carbonyl)-3,4-dihydro-2H-1,4-benzoxazine-7-carbonitrile

There total 4 articles about 4-({3-[4-(trifluoromethyl)phenyl]imidazo[1.2-a]pyrazin-6-yl}carbonyl)-3,4-dihydro-2H-1,4-benzoxazine-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 566158-19-8
C₉H₈N₂O

: 1607830-54-5
3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxylic acid

: 1610670-55-7
4-({3-[4-(trifluoromethyl)phenyl]imidazo[1.2-a]pyrazin-6-yl}carbonyl)-3,4-dihydro-2H-1,4-benzoxazine-7-carbonitrile

Guidance literature:: 3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 0.0833333h;

C₉H₈N₂O; With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 54013-06-8
ethyl 5-aminopyrazine-2-carboxylate

: 1610670-55-7
4-({3-[4-(trifluoromethyl)phenyl]imidazo[1.2-a]pyrazin-6-yl}carbonyl)-3,4-dihydro-2H-1,4-benzoxazine-7-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / water; ethanol / 16 h / 90 °C

2.1: N-Bromosuccinimide / dichloromethane / 3 h / 20 °C

3.1: tris-(o-tolyl)phosphine; potassium fluoride; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / water; toluene; methanol / 0.33 h / 110 °C / Microwave irradiation

3.2: 3 h / 20 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.08 h / 20 °C

4.2: 1 h / 20 °C

With potassium fluoride; N-Bromosuccinimide; oxalyl dichloride; sodium hydrogencarbonate; N,N-dimethyl-formamide; tris-(o-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In methanol; ethanol; dichloromethane; water; toluene; 3.1: |Suzuki Coupling;

Reference yield:

: 588720-67-6
ethyl pyrrolo[1,2-a]pyrazine-3-carboxylate

: 1610670-55-7
4-({3-[4-(trifluoromethyl)phenyl]imidazo[1.2-a]pyrazin-6-yl}carbonyl)-3,4-dihydro-2H-1,4-benzoxazine-7-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide / dichloromethane / 3 h / 20 °C

2.1: tris-(o-tolyl)phosphine; potassium fluoride; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / water; toluene; methanol / 0.33 h / 110 °C / Microwave irradiation

2.2: 3 h / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.08 h / 20 °C

3.2: 1 h / 20 °C

With potassium fluoride; N-Bromosuccinimide; oxalyl dichloride; N,N-dimethyl-formamide; tris-(o-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In methanol; dichloromethane; water; toluene; 2.1: |Suzuki Coupling;