(R)-2-(4-isobutylphenyl)-N-(3-tert-butoxycarbonylaminopropyl)propionamide

Base Information

• Chemical Name: (R)-2-(4-isobutylphenyl)-N-(3-tert-butoxycarbonylaminopropyl)propionamide
• CAS No.: 454701-77-0
• Molecular Formula: C₂₁H₃₄N₂O₃
• Molecular Weight: 362.513

Synonyms:(R)-2-(4-isobutylphenyl)-N-(3-tert-butoxycarbonylaminopropyl)propionamide

Chemical Property of (R)-2-(4-isobutylphenyl)-N-(3-tert-butoxycarbonylaminopropyl)propionamide

Chemical Property:

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Technology Process of (R)-2-(4-isobutylphenyl)-N-(3-tert-butoxycarbonylaminopropyl)propionamide

There total 5 articles about (R)-2-(4-isobutylphenyl)-N-(3-tert-butoxycarbonylaminopropyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

N-Boc-1,3-diaminopropane (75178-96-0) + (R)-ibuprofene (51146-57-7,58560-75-1) → (R)-2-(4-isobutylphenyl)-N-(3-tert-butoxycarbonylaminopropyl)propionamide (454701-77-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 20 - 25 ℃; for 18h;

Reference yield:

(R)-ibuprofene (51146-57-7,58560-75-1) → (R)-2-(4-isobutylphenyl)-N-(3-tert-butoxycarbonylaminopropyl)propionamide (454701-77-0)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 3 h / Heating

2: 4.8 g / Et₃N / CH₂Cl₂ / 4 h

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1021/jm049082i

Reference yield:

(R)-2-(4-isobutylphenyl)propionyl chloride (114978-05-1) + N-Boc-1,3-diaminopropane (75178-96-0) → (R)-2-(4-isobutylphenyl)-N-(3-tert-butoxycarbonylaminopropyl)propionamide (454701-77-0)

Guidance literature:

With triethylamine; In dichloromethane; for 4h;

DOI:10.1021/jm049082i

upstream raw materials:

(R)-2-(4-isobutylphenyl)propionyl chloride

N-Boc-1,3-diaminopropane

(R)-ibuprofene

3-bromopropylamine tert-butylcarbamate

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